Department of Biophysics

ABOUT

THE DEPARTMENT OF BIOPHYSICS

Biophysics is the physics of life phenomenon studied at all levels, from molecules and cell to the biosphere as a whole. It is the branch of knowledge that applies the principles of physics and chemistry and the mathematical analysis and computer modeling to understand how biological system work. The main emphasis of biophysics is on the quantitative analysis of the physical and chemical aspects of the functions of biological molecules, organisms and entities. The techniques and methodologies that biophysics relies on are closer to Physics and Chemistry, but areas of application are in the biological, medical and related sciences.

The Department of Biophysics has been established by the University of Mumbai at Vidyanagari Campus in 2001-2002, provides training to students with interest of offering M. Sc. (Biophysics) and Ph.D. (Biophysics) courses. The sole aim of the department is a making a high class of globally recognized “Centre of Excellence” in the field of Interdisciplinary areas of Science education training and research in the campus of University of Mumbai. The department offers M.Sc. and Ph.D. degrees. The students are admitted to M.Sc. programme on the basis merit at B.Sc. level. The quantitative area covered under M.Sc. course such as Molecular and Cellular Biophysics, Radiation and Medical Biophysics, Biophysical Techniques, Bioinformatics and Molecular Modeling, X-ray Crystallography, rDNA technology and protein engineering, Environmental Biophysics, Nanobiophysics & Nanomedicine etc. are major emphasis is given to hands on practical training to the students.

Adjunct faculties, Scientist and experts from other Research Institutes and University Departments participate in the teaching program. Scientists, and Professors from other Institutes and University invite seminars on specialized areas of Biophysics. The teaching and research laboratories in the department are well equipped with all necessary equipments. The Department has its own Library. Special efforts are taken to update the collections with latest Textbook and Scientific Journals. The students of the department are provided with internet facility to access relevant research of the subject and also the components in other disciplines. Every student is required to complete a small research project during the second year of the program. The special efforts are taken by the department for the students who appear for National Test for junior research fellowship and lectureship and test conducted by UGC/CSIR and other National Institutes. Along with the hectic teaching program the department also organizes Social, Cultural and Personality development programs, which again help the fulfillment of the student’s progress. The funds for the research are being arranged from various donor agencies like UGC, CSIR, DST, DBT, DRDO, DAE and NGO’s

ABOUT THE SUBJECT

Biophysics is the integration and application of the principles of physics and physical chemistry to explain and explore the form and function of living things. It is an interdisciplinary science that applies the principles of Physics, Chemistry, Maths and Computer Modelling to understand how biological systems work. Biophysics explains biological function in terms of the molecular structures and their properties. It is a bridge between biology and physics. It is a highly fascinating and intellectual field and the very root of our existence. The term biophysics was originally introduced by Karl Pearson in 1892. Principles of physics have been used to explain some of the most basic processes in biology such as osmosis, diffusion of gases, and the function of the lens of the eye in focusing light on the retina. Biophysicists study how organisms develop, see, hear, think and live. They investigate how the brain processes and stores information, the heart pumps blood, muscles contract, plants use light in photosynthesis, genes are switched on and off and many other such questions.

The foundations for the study of biophysics were laid down in the 19th Century, by a group of physiologists in Berlin. The Berlin school of physiologists included Hermann von Helmholtz, Emil DuBois-Raymond, Ernst von Brücke, and Carl Ludwig. In 1856, Adolf Fick, one of Ludwig’s students, published the first biophysics textbook. But technology in physics had not sufficiently advanced at this time to study life forms in a detailed way, such as at the molecular level. In the first half of the 20th Century, German scientists dominated biophysics. They studied electromagnetic fields and light, and they became mainly concerned with studying the effects of radiation on living things. The popularity of biophysics rose when the Austrian physicist Erwin Schrödinger published the book, What is Life? in 1944. This book was based on a series of public lectures that Schrödinger gave on explaining the processes of living things through physics and chemistry. In it, he proposed the idea that there was a molecule in living things that contained genetic information in covalent bonds. This inspired scientists such as James Watson and Francis Crick to search for and characterize the genetic molecule, and with the aid of Rosalind Franklin’s X-ray crystallography research, they discovered the double helix structure of DNA in 1953. By the mid-20th century, biophysics programs had sprung up and gained popularity in other countries, and from 1950-1970, biophysics research occurred at a faster rate than ever before.

Biophysical methods are increasingly used to serve everyday needs, from forensic science to bioremediation. Medical imaging technologies including MRI (Magnetic Resonance Imaging), CAT (Computed Axial Tomography) scans etc. are the invention of Biophysics. Biophysics shares a strong bond with other advanced biological fields biochemistry, bioengineering, systems biology, nanotechnology etc. Biophysics incorporates the study of all levels of biological organization, from molecules to ecosystems. Sir JC Bose was the first Indian Biophysicist. His major contribution in the field of biophysics was the demonstration of the electrical nature of the conduction of variousstimuli (wounds, chemical agents) in plants, which were earlier thought to be of a chemical nature. He also studied for the first-time action of microwaves in plant tissues and corresponding changes in the cell membrane potential, mechanism of effect of seasons in plants, effect of chemical inhibitor on plant stimuli and effect of temperature. Another great Indian biophysicist G.N. Ramachandran is famous for Ramachandran plot which is an elegant visual representation of secondary protein structure. Both of these scientists were Institution builders as well. JC Bose founded Bose research Institute at Kolkata whereas GNR established Department of Biophysics in University of Madras. Prof G. Ramachandran is also the founder of Molecular Biophysics Unit (MBU, 1971) at Indian Institute of Science, Bangalore. Another pioneer of Indian Biophysics is Prof. Girjesh Govil, from Tata Institute of Fundamental Research, Mumbai. He is known for his research in Nuclear Magnetic Resonance (NMR) and semi-empirical quantum chemical theories. He has been awarded the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1978, for his contributions to chemical sciences.

CONTACT

Address:
Department of Biophysics, Mumbai University, Kalina campus Mumbai, India

Email id: drpmdongre@yahoo.co.in

Phone: 022 26524288, 26543105, 26543492

PROGRAMMES

COURSES & SYLLABUS

a) M.Sc (Biophysics) by Papers; b) PhD (Biophysics)

  1. Post graduate (M.Sc. by Papers, (choice-based credit system)):

The two-year M.Sc. (Biophysics) programme is prescribed according to the choice- based credit system of the University of Mumbai from the academic year 2016-17.

The chief areas covered under the program:

  • Molecular and Cellular Biophysics
  • Radiation and Medical Biophysics
  • Advanced Biophysical Techniques
  • Bioinformatics, Molecular Modeling & Drug Design
  • Spectroscopy & Bio-crystallography
  • Nanobiophysics & Nanomedicine
  • Physiological Biophysics
  • Environmental biophysics
  • rDNA Technology & Protein Engineering
  • Biostatistics and Biomathematics
Semester I
Paper code Paper Nomenclature Lectures Credit Practical/

Laboratory course

Hrs. Credits Total Credits
BP-CCT 101 General physico-chemical Principles 60 04 Lab course (BP- LBC) 101 60 02 06
BP-CCT 102 Biomathematics & Biostatistics 60 04 Lab course (BP- LBC)

102

60 02 06
BP-CCT 103 Cellular Biophysics 60 04 Lab course (BP- LBC)

103

60 02 06
BP-CCT 104 Methods in Biophysics 60 04 Lab course (BP- LBC) 104 60 02 06
Total 24
Semester II
BP-CCT 201 Membrane Biophysics & Ion channels 60 04 Lab course (BP- LBC) 201 60 02 06
BP-CCT 202 Molecular Biophysics 60 04 Lab course (BP- LBC) 202 60 02 06
BP-CCT 203 Biochemistry 60 04 Lab course (BP- LBC) 203 60 02 06
BP-CCT 204 Recombinant DNA Technology & Protein

Engineering

 

60

 

04

Lab course (BP- LBC)  

60

 

02

 

06

204
Total 24

 

 

Semester III
Paper code  

Paper nomenclature

 

Lectures

 

Credit

Practical no. and Code  

Hrs.

 

Credit

Total credits
PB-CCT 301  

Physiological Biophysics

 

60

 

04

Lab course I (BP-LBC 301)  

60

 

02

 

06

BP-CCT 302 Bio crystallography & Magnetic Resonance

Techniques

 

60

 

04

Lab course II (BP-LBC 302)  

60

 

02

 

06

BP-CCT 303  

Radiation Biophysics

 

60

 

04

Lab Course III (BP-LBC 303)  

60

 

02

 

06

 

PB -CCT 304

 

Advanced in Biophysical Techniques

 

 

60

 

 

04

Lab Course IV Research Project

/Review

literature

 

 

60

 

 

02

 

 

06

Total 24
Semester IV
BP-CCT 401  

Medical Biophysics

 

60

 

04

Lab Course I (BP-LBC 401)  

60

 

02

 

06

BP-CCT

402

Environmental Biophysics 60 04 Lab Course II

BP-LBC 402

60 02 06
BP-CCT 403 Nanobiophysics and nanomedicine  

60

 

04

Lab Course III (BP-LBC 403)  

60

 

02

 

06

 

BP-CCT 404

Elements of Bioinformatics, molecular modeling and drug design  

60

 

04

Lab Course IV (BP-LBC 404)

Research

Project

 

60

 

02

 

06

120 24
Total 24
Grand Total (Sem I, II,

III & IV)

96
Total credits (M.Sc.) = 96

Detailed syllabus M.Sc I (PDF)

Detailed syllabus M.Sc II (PDF)

PROGRAM OUTCOME

The knowledge of this program will provide an intellectually enlarging experience to students.  The courses attempt to teach critical thinking, problem solving, and communication skills that can be used throughout a life of learning. The program helps to prepare students and make them competitive to enter in the workforce or further their studies in research (Ph.D) at professional colleges, pharmaceutical / biomedical industries, medical schools, Universities  etc.

After completing the M.Sc . in  Biophysics  Program at  University department of Biophysics, the     students will be able to acquire the following skills:

  1. Students will demonstrate proficiency in principles of physics, chemistry and mathematical concepts that are needed for a proper understanding of biological process.
  2. Students will be able to Integrate knowledge and skills of the physics, chemistry & mathematics with biology and to address research questions.
  3. Students will demonstrate knowledge of cell & molecular biology, methods in biophysics, radiation & medical biophysics, physiological biophysics, structure –functions of biological macromolecules, biomathematics and biostatistics, biochemistry & protein engineering, molecular modeling & drug design etc. .
  4. Students will show that they have learned laboratory skills, enabling them to purify and characterize biological samples using various spectroscopic and microscopic tools. They will be able to collect, evaluate and interpret scientific data, and employ critical thinking to solve problems in biology  and supporting fields  .
  5. Students  will demonstrate  knowledge of various spectroscopy, microscopy and other     analytical tools that are used in biology
  6. Students will communicate scientific information in a clear and concise manner both orally and in writing.
  7. Student will identify and describe the impact of biophysics  on society.

Program specific outcome  (PSO) :

A Master’s degree of Biophysics will  provides  theoretically and practically  a broad  foundation  in biophysics with particular focus on  cell and membrane biophysics, advanced biophysical techniques, structural biology, radiation and medical biophysics, physiological biophysics, molecular modeling and drug design, environmental biophysics.

In particular, this study includes in depth learning about the structure and function of important biomolecules and cellular systems, biophysical tools as well as physiological biophysics. Students will also learn about methods of protein purification and characterization, measuring the effects of radiation on biological systems, understanding fundamental principles of various biophysical techniques (Fluorescence spectroscopy & Microscopy, UV visible, FTIR, NMR, ESR,  Raman Spectroscopy and other  light scattering) etc. This study will lead further towards problems in medicine, medical physics, use of techniques in radiation for cancer therapy and diagnosis, applications of various spectroscopy tools in biology and medicine.

During the study of this Master’s degree course, the students will also learn fundamental scientific working methods, for example, to work independently on a large-scale project, to design research project, to write scientific contents / research papers and presentation etc.

Course outcome (CO):

 Term Course  code Outcome
 

Semester I

BP-CCT101 General Physico-chemical principle: objectives of this course is fundamental understanding of physical, chemical principle which help for quantitative  underrating of biological process.

Course  outcomes:

By the end of this course the students should be able to develop an understanding of the process of biological system.

 

BP-CCT102 Biomathematics & BiostatisticsObjectives of this course is basic understanding of statistics and mathematics which help the students for quantitative prediction of biological data.

 Course outcomes: by  the end of this course students understand basics concepts of statistics  and mathematics  such as mean mode, median, std deviation, types of hypothesis & tests, limits & functions, probability etc.

 

BP-CCT103 Cellular Biophysics: objective of this is to understand fundamentals of various types of cells, their structure and function, physical aspects of cells etc.

Course outcomes: by the end of this course, the students should able to understand the principles underlining cell function, cell differentiation, cell growth, cell communication etc.

 

BP-CCT104 Methods in Biophysics:  objective of this course is to familiarize students with various biophysical methods such electrophoresis, UV visible spectroscopy, fluorescence spectroscopy, circular dichroism, microscopy ( bright field, dark field, fluorescene, SEM, TEM etc).

Course outcomes:

By the end of the course the student able to understand basics principles of spectroscopic and microscopic techniques and their applications in biological and medical sciences.

 

BP-LBC101 Lab course I: objectives of this course is to provide practical training to the students of handling some important equipments, standardization of pH meter, verification of spectroscopic laws and principle etc.

Course outcomes: at the end of  the course, the students familiarize with handling of some equipments, understand properties /measurements of biological samples

 

BP-LBC102 Lab course II: This course is specially designed specifically statistical analysis of  experimental / biological data.

Course outcomes: At the end of this course the student able to statistically evaluate experimental data and its statistical interpretation.

BP-LBC103 Lab course III: The objectives of this course is to familiarize the students with microscopic techniques, handling of microscope, sample preparation of microscope etc.

Course outcomes: by the end of the course the students  should  develop skill of handling of microscopes, study of various biological samples, cell etc

 

BP-LBC104 Lab course IV: objectives of the course is to develop a skill of separation of proteins, carbohydrates, lipids using various biophysical tools.

Course outcomes: by the end of this course students able to familiarize separation techniques, able to separate and characterize biological samples.

Semester II BP-CCT201 Membrane biophysics and Ion channels: The objectives of this course is students understand physics of membrane, membrane structure, function,  lipid technology etc.

Course outcomes: at the end of the course students should be able to understand various physical and chemical aspects of cell membrane, cell membrane functions etc.

 

BP-CCT202 Molecular Biophysics:  The objective of this course is to understand structure and function, stability of biological macromolecules (enzyme, protein, lipids, nucleic acids etc).

Course outcomes: by the end of the course student should be able understand the structure  of protein, lipid, carbohydrates. Techniques use to study protein stability, protein folding and significance in biological system.

BP-CCT203 Biochemistry: This course provides insight of biochemical pathways, signals, cellular level synthesis of biological macromolecules, gene expression in prokaryotes and eukaryotes etc.

Course outcomes:  By the end of this course the student able to discuss mechanisms of various pathways takes place in biological system, their impact on biological system, mechanism and regulation of gene expression

 

BP-CCT204 rDNA Technology  & Protein Engineering: This course provides students to understand preparation , analysis and manipulation of DNA & RNA, construction of rDNA libraries, mutagenesis, methods of protein sequencing and chemical approach to protein engineering etc.

Course outcomes: by the end of this course student able to learn manipulation of genetic materials, construction of recombinant DNA libraries, sequencing strategies of proteins..

 

BP-LBC201 Lab course I : the objectives of the course is to provide practical knowledge of physical and chemical aspects of  biological macromolecules (DNA, RNA, Hemoglobin, Sugars)..

Course outcomes: by the end of the course students will understand physical and chemical aspects of biological macromolecules, they will learn study of these molecules using spectroscopic techniques.

BP-LBC202 Lab course II : objectives of the course is to provide hands-on training on estimation of proteins from unknown source, performance of enzyme kinetics experiments etc.

Course outcomes:  by the end of the course students will able to isolate and identify the proteins from various sources, student will able to carry enzyme kinetics reaction, they can understand physical and chemical aspects of enzyme reactions.

 

BP-LBC203 Lab course III : objectives of the course is to train students for isolation of nucleic acids from various sources, characterize it using various biophysical tools.

Course outcomes : at the end of the course students will familiar with isolation of nucleic acid,  restriction endonuclease principle, chromatography techniques ( Gel & paper).

 

BP-LBC204 Lab course IV: objective of the course to train  students   for preparation and characterization  of artificial membrane. Experimentally study the physical aspects of  membrane, membrane properties etc.

Course outcome: by the end of course students will able to gain practical knowledge of  preparation of artificial membrane, students  will be trained for designing the experiments related to cell membrane.

Semester III BP-CCT301 Physiological Biophysics: this course will provide insight into functional  aspects of various human organs,  physical and chemical aspects of various organs.

Course outcomes : at the end of the course student able to understand basics physiological function of various organs.

 

BP-CCT302 Biocrystallography & Magnetic Resonance Techniques: This course will provide basics principals and fundamental understanding of NMR and its various types, ESR, X-Ray diffraction techniques etc.

Course outcomes:  by the end of the course students will be familiar with fundamental understanding of magnetic resonance technique and their applications..

BP-CCT303 Radiation Biophysics : objectives of the course is to understand  the interaction of radiation with matter, living system, biological effects of ionizing and non ionizing radiation etc.  Assessment of radiation effects using various mathematical models.

Course outcomes: by the end of course students will gain the basic principle of interaction of radiation with matter and living system, they will be familiar with the knowledge of ionizing radiation and its impact on biological system.

BP-CCT304 Advanced Biophysical Techniques: Objectives of the course is to make the students familiar with advanced biophysical  techniques such as Differential Scanning colorimetry, Mass spectrometry, force spectroscopy, cryo electron microscopy, patch clamp techniques etc.

Course outcomes:  by the end of the course student will gain the knowledge of advanced biophysical techniques, they will understand basics principals and applications in biology and medicine.

 

BP-LBC301 Lab course I: the course will provide practical knowledge of analysis of  DNA damage  using physical and chemical methods, protein folding study, ligand binding interaction using SPR, protein structure study using CD ORD, protein-protein interaction using fluorescence spectroscopy, use of fluorescence and differential contrast microscopy for biological samples, protein aggregation etc.

Course outcomes: by the end of the course students will gain insight into practical knowledge of DNA damage analysis, protein structure, protein –protein interactions. Students will also become familiar with handling of advance equipments ( fluorescence microscope CD ORD, SPR etc).

 

 

BP-LBC302 Lab course II:  objectives of the course is to provide hands on training of measurement of various surface potentials ( ECG, EEG, ERG, EMG, EOG, etc) , to train students for recording of  surface potential and analysis.

Course outcome: by the end of the course student will be able record  and analysis human surface potentials (EEG,ECG, EMG, EOG etc), they will able to interpret inference in normal and abnormal biopotentials.

 

BP-LBC303 Lab course III :objectives of the course is to train students with radiation biophysics  experiments. They will train for analysis of radiation effects on biological systems (cells, biological macromolecules), estimation of absorbed dose, study of GM counting system etc.

Course outcomes: by the end of the course students will gain knowledge of radiation biophysics, they will able to design  radiation biology experiments. Student will able analysis radiation effects on biological system etc.

 

 

BP-LBC304 Lab course IV: objectives of the course is student understand literature survey on particular areas, material and methodology used in research, how to  write/ interpret  results and discussion, how to design  experiments, how to use various tools for collection of literature,  how organize bibliography etc.

Course outcomesby the  end of the course students will be able to design of experiments, they will able to analysis of experimental data, they will able to discuss the results obtained on particular problem.

 

Semester IV BP-CCT401 Medical Biophysics: This course will provide basics of radiotherapy, nuclear medicine and diagnostics radiology, basics of radiation  protection.

Course  outcomes: at the end of the course students will understand fundamental principles of radiation therapy, radio diagnosis , radiation protection and application radiation in medicine. Role of isotopes in medical diagnostics

 

BP-CCT402 Environmental Biophysics: Aim of the course is to know the importance of environment, life and environment, Electromagnetic radiation and environment etc. conductance of heart and mass transfer etc.

Course outcomes: at the end of course student will able to familiar with environment and its importance to human being.

BP-CCT403 Nanomedicine and Nanobiophysics: objectives of  the course is to familiar the students with  nanosciences and nanotechnology, understand basics principles of synthesis  of nanostructures, nanotoxicology and application of nanostructures in medicine and biology.

Course outcomes : by the end of course students will able to gain knowledge of nanomedicine, nanostructures. Various applications of metallic nanostructures in medicine and biology.

 

BP-CCT404 Elements of Bioinformatics, Molecular modeling and drug design:  this course will provide fundamental understanding of bioinformatics, structural bioinformatics, molecular mechanics, denovo ligand and 3D QSAR

Course outcomes : by the end of the course students able to gain knowledge of molecular modeling and drug design, they will able to discuss virtual screening etc.

BP-LBC401 Lab course I: aim of the course is train the students to synthesis and characterize nanostructures, development of nanostructure application in medicine and biology.

Course outcomes: by the end of the course students able to synthesis and characterize nanostructures  using various sources (biological, chemical).

BP-LBC402 Lab course II: aim of the course to expose the students to advanced techniques like Raman Spectroscopy, FTIR, Dynamic Light scattering technique, etc

Course outcomes: at the end of course students will able to understand and use of advance techniques for characterization of biological samples.

BP-LBC403 Lab course III: objectives of the course is develop skill of preparation of bioinformatics database, phylogenic analysis, construction of biomolecule using different tools, analysis of protein-ligand interaction using docking software’s.

Course outcomes: by the end of the course students will be to analysis / characterize biomolecuels using various softwares, they will able to predict protein structures, gene annotation etc.

BP-LBC404 Lab course IV: objectives of the course is to prepare students for research skill, they will learn design of experiments, identification of research problem, how to develop hypothesis, project writing skill, data presentation, writing discussion, bibliography preparation etc.

Course outcomes: at the end of course student will be able to design research hypothesis, objectives of research problem, identify suitable material and methods, collect review literature, writing and presentation of research project etc.

 

 

 

Ph.D. (Biophysics) Programme

The Ph.D. Degree (in Biophysics): involves submission of Dissertation / Thesis to the University based on the research conducted under the supervision of a faculty member (who are recognized teachers of the University for guiding students for Ph. D degree) working at the Department of Biophysics. Students with Master’s Degree (M. Sc) in Sciences (as per the University circular No. 441 of 2005 & VCD’s) are entitled to seek admission for Ph.D. programme of Biophysics.

Program outcome:

The Ph D program in Biophysics has been started in 2007-2008.  The students having post graduate in Biophysics/ Biochemistry/Physics / allied branches of life sciences can enrolled for PhD course.

The PhD program is designed to prepare each student to actively participate in the development and growth in the field of biophysics at all levels in industry / teaching in Universities/ Institutes.  The students research training enhanced by organizing seminars, discussions, invitation  of  world renowned Scientists/ Professors for special lecture, Journal club activity etc. The students will demonstrate depth knowledge  of  various biophysical tools such as  fluorescence spectrophotometer, Raman spectrophotometer, FT-IR, Fluorescence Microscopy, UV Visible spectrophotometer, Fluorescence Microscope, Dynamic Light Scattering, Atomic Force Microscope (Bio AFM), Surface Plasmon Resonance Analyzer, single and 2-D gel electrophoresis. The research projects span across a broad range of topics covering various aspects of structure-function of biological macromolecules; nanostructure-biomolecule interaction; nanostructure based snake venom inhibitor; nanostructure based targated drug delivery system, tumor targeting proteins etc.

ELIGIBILITY & FEES

Eligibility for M.Sc

B.Sc. / B.Sc. (Hons) majoring in Biophysics/Physics/Chemistry/Biochemistry/Microbiology/ Biotechnology/ Forensics science/ Bioinformatics/ any branch of biology with chemistry or physics/ B. Tech (Biotechnology /Bioinformatics). A candidate must have secured minimum 50% marks at B.Sc. examination in the major subject for open candidates. For reserved candidates, University rules and regulation apply.

Fees Structure

The total numbers of seats are 20, out of which seats are allotted to reserve categories as per the rules and regulation of Govt. of Maharashtra and 3% seats are reserved for the students from other universities other than Mumbai University.

Revised Fee structure for M.Sc. courses (wef from the academic year 2009-2010)

Sr. No Particulars Amount Rs.
1 Tuition fee 15,000/-
2 Forms and Prospectus 100/-
3 Other fees/ Extracurricular activities 250/-
4 University exam fee 600/-
5 Mark sheet 50/-
6 Laboratory fee 15,000/-
7 Library 1000/-
8 Gymkhana 200/-
9 Admission processing fee 200/-
10 Vice Chancellors fund 20/-
11 Magazine 100/-
12 Identity card 50/-
13 Group Insurance 40/-
14 Student welfare 50/-
15 University sports and Cultural activities 30/-
16 Development fee 500/-
17 Utility 250/-
18 Computer/Internet 500/-
19 e-suvidha 50/-
20 e-charges 20/-
21 Disaster relief fund 10/-
Total 34,020/-

Note: some fee heads may change time to time

Document verification: 400/- wherever applicable

Refundable deposit Caution Money: 150/-

Library Deposit: 250/-

Laboratory deposit: 400/-

Project fee: 2000/- (wherever applicable)

Registration fee for M.Sc. Part I only: 1000/-

Convocation fee only for MSc. Part II: 250/-

  1. NB. Foreign students will have to pay five times of prescribed fees. The fees collected in different heads be spend only for specified purpose for which it has been collected.

Fees are payable by cash in the Allahabad Bank, Kalina Branch, Wadia High School, Ground Floor, Opp. University Campus.

  • Tuitions fees once paid are normally not refunded. However, tuition fees will be refunded if the candidates do not attend any theory/practical/seminar class. Application for refund of fees should be addressed to the Registrar, University of Mumbai in duplicate.
  • No transference Certificate will be issued to the students who leave the Department, unless they clear all the dues.

Eligibility for PhD:

  • Should have M.Sc. degree in Biophysics with minimum 55% marks.
  • Candidates qualified in ICMR-JRF/DBT-JRF/CSIR-JRF/ GATE examination under Life Sciences/Biotechnology or PET Biophysics (University of Mumbai) can also apply.

Admission will be subject to their qualifying the departmental interview.
All the applications will be screened and candidates found suitable will be called for interview. Travelling Allowance is not payable by University Department of Biophysics and candidates have to make their own arrangement for stay at Mumbai. Merely fulfilling of the minimum requirements stipulated in the notification would not automatically entitle a person for selection. The decision of the department in this regards shall be final. Applications will be accepted only upon advertisement of PhD notification displayed on Mumbai University website.

STAFF

FACULTY

Dr Prabhakar M Dongre ,
M.Sc, PhD (Biophysics)
Prof. & Head

Prof Prabhakar Dongre  graduated with Physics, Chemistry and Electronics as a major subjects;   Masters and Ph D in Biophysics from Dr Babasaheb Ambedkar Marathwada University, Aurangabad. Prof Dongre started his career from 1997 by joining MIMSR Medical College, Latur as Assistant Professor (Biophysics) in the department of Physiology. Prof Dongre has joined in the University of Mumbai, Department of Biophysics since 2006.

Prof Dongre and his research team are keen interest to understand the mechanisms of interaction of biological macromolecuels (proteins) with  nanoparticles which is essential to develop applications in medicine and biology. His team is quantitatively assessing structure- functions of proteins upon adsorption on metallic nanoparticle surface. Recently his research team explored the possibility of nanoparticle act as a snake venom inhibitor, uploading anticancer drugs  on protein-nanoparticle conjugates for targeted drug delivery.  Professor Dongre digitized several radiosensitizers and radioprotectors and that have been uploaded on Mumbai university website for free use to investigators/ clinicians/ scientists etc.

A quality research papers has been published in internationally reputed research journals.   Four patents are on his credit and one is in progress. He successfully completed three major research projects financially supported by Department of Atomic Energy (BRNS), Defence Research Development Organization and Department of Science and Technology, Govt of India.

He has been given representation on International Union of Pure and Applied Biophysics (IUPAB 2012- 2016), He served as Vice president of Indian Biophysical Society, Executive member of Society for Radiation Research. He worked as senator (VC nominee) and committee member on various committee of Mumbai University. He is Chairperson of Ad hoc board studies in Biophysics, RRC member Biophysics, Board of studies member of Medical Physics (SRTMU , Nanded), Physics ( Sophia College, Mumbai) , Academic council member of Mithibai College, Mumbai etc. Prof Dongre has been awarded best academician and researcher by Maharashtra Marathi Mandali, Mauritius. He was invited by Department of Biotechnology for the participation in Noble Lecture Series India 2018, which organized by the Department of Biotechnology, Govt of India to discuss the transformation of basics research in to technology development. He has been awarded for best publication of the year by Biophysical Society of Japan for the year 2019. He has been Best Teacher Awardees (2018-19) of Mumbai University  and Best Faculty awardees  (2018-19) of  Computer Society of India, Mumbai Chapter.

 

Prof. B. S. Rao, Adjunct faculty

Dr. Badanidiyoor Srinivasa Rao joined as Adjunct Professor in the department of Biophysics after superannuation from BARC, Mumbai. He started his service as a scientific officer at BARC after graduating from the 12th batch of BARC training school in 1969. He obtained his Ph. D degree in biophysics in 1978 from the erstwhile Cancer Research Institute. During his post-doctoral studies in (1980-82) he undertook mammalian cell radiobiology in the department of Therapeutic Oncology MCMC, Wisconsin, USA. His research activities have been mainly in the areas of biophysical aspects of radiation quality, radiobiology, radiation cytogenetics and mutagenesis. He was a recipient of Madam Marie Curie fellowship of the European Commission in the year 1995 and worked on the application of translocation essay in biodosimetry at the University of Leiden, The Netherlands. He has served as an IAEA expert in biodosimetry. He had the honor of being on the Editorial Board of International Journal of Radiation Biology (UK). He also edited the Journal of Radiation Protection and Environment, and EMSI newsletter for several years. He retired from BARC in 2005 as the Head of Radiological Physics and Advisory Division.

 

Prof. S. Sivakami, Adjunct faculty

Prof. (Mrs.). S. Sivakami joined as an adjunct professor at the Department of Biophysics after superannuation from Department of Life Sciences, University of Mumbai. She has obtained her PhD from the Christian Medical College, Vellore, Tamil Nadu and had postdoctoral training from the University of Leeds, UK, University of Georgia, USA and University of California, Santa Cruz, California, USA. Her main research interests are in the area of biochemical characterization of enzymes. She has worked on the glycosidases of the brush border membrane of small intestine and kidney of experimental animals, antioxidant enzymes in experimentally induced diabetes and non-enzymic glycation in diabetes. More recently she has studied some enzymes of biotechnological potential from the Cyanobacterium Spirulina platensis. She has been a visiting professor at the National University of Singapore on several occasions. She has published several research papers in reputed national and international journals as well as authored review articles, popular articles as well as a book chapter. She is a fellow of the Maharashtra Academy of Sciences, fellow of the TWOS, Trieste, Italy and a member of the editorial board of Indian Journal of Biochemistry and Biophysics.

 

Prof. Ramakrishna V. Hosur, Honorary Professor

Prof. Ramakrishna Vijayacharya Hosur has done Ph.D. from TIFR in 1978. He is an Indian biophysical scientist, known for his expertise in the areas of nuclear magnetic resonance and molecular biophysics. The Government of India honoured him, in 2014, by awarding him the Padma Shri, the fourth highest civilian award, for his contributions to the fields of science and technology Currently, Sir is Honorary Professor in department of Biophysics University of Mumbai. Professor has made important contributions in the area of Biomolecular NMR, Structural Biology and Biophysical Chemistry. Developed new multidimensional NMR techniques, novel strategies and software packages for quantitative macromolecular structure determination. These have led to determination of atomic resolution solution structures of important nucleic acid segments. Duplexes containing cognate sites of specific proteins and unusual DNA forms have been investigated. Presently working on the structures and dynamics of large proteins, protein- protein complexes and multistrand nucleic acid structures by NMR and other spectroscopic methods. The proteins are produced by gene cloning methods.

 

Prof. Grijesh Govil, Visiting faculty

Prof. Girjesh Govil is Visiting Professor in the Department of Biophysics (TIFR, Mumbai). Girjesh Govil earned his BSc degree from Lucknow University and MSc degree from Allahabad University. Then he joined the Bhabha Atomic Research Centre (BARC) and later moved to Tata Institute of Fundamental Research (TIFR) in Mumbai, and earned his PhD degree from University of Mumbai. He did his post- doctoral Fellowship at National Physical Laboratory in UK, and National Research Council (NRC) Canada. Later, he served as Visiting Scientist at NRC. The National Institute of Health/ USA and Kobe University, Japan, Govil served as senior Professor. Raja Ramanna Fellow and is presently INSA Golden Jubilee Research Professor at TIFR, Mumbai.

 

Prof. A. V. Chitre, Visiting faculty

Dr. A.V. Chitre is a biophysicist and an adjunct faculty of Department of Biophysics. He has worked as Analytical Chemist (FDA, Maharashtra) and Scientific Officer (Radiation Medicine Center, BARC). He has been the Head, Dept. of Chemistry, Vice Principal (Science); Professor Emeritus & Research guide in Physical Chemistry in Sophia College. He has worked as a research assistant at University of N. Carolina, USA and Wayne state University, USA. He has been awarded D. Mahendra award; Indo-US Fulbright fellowship.

 

Dr. Sandhya P Kulkarni, Visiting faculty

Mrs. Sandhya Kulkarni is visiting faculty of the department of Biophysics since 2002. She is former Assistant Professor of Biophysics, Department of Physiology, BYL Nair Hospital & T N Medical College, and Mumbai. Currently she is working as an Associate Director of New Horizons Child Development Centre, Mumbai. Her areas of interest are physiological biophysics, Radiation & Medical biophysics.

 

 

Dr. Avinash Kale, Visiting faculty

Dr. Avinash Kale biophysicist and a visiting faculty of Department of Biophysics. He is obtained Ph.D. in Protein crystallography, Rijks university its Groningen, Groningen, the Netherlands. (Dec 2002- 2007). Masters in Physical chemistry, Indian Institute of Technology, Bombay, India (March 2001). Bachelors in Chemistry Honors, Holkar Science College, Indore, India (March 1998). Visiting Assistant Professor- Centre for Excellence in Basic Sciences, Mumbai, India (May 2016 – Visiting Scientist-II – Centre for Excellence in Basic Sciences, Mumbai, India (Apr 2013 – Apr 2016) Research Associate (RA-3) -Center for Excellence in Basic Sciences, Mumbai, India (Jan 2013 – Mar 2013). Visiting Scientist – Bhabha Atomic Research Center, Trombay, Mumbai, India. (Nov 2011- Dec 2012). Post-doc Scientist – University of Oulu, Oulu, Finland. (Apr 2011-Sep 2011). Post-doc Research Associate (PDRA) – University of Sheffield, Sheffield, United Kingdom. (Jan2008- Dec 2010). Project Assistant – Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India. (May 2001- Oct 2002). Research areas: Actin regulation; Mosquito Borne Diseases; ageing in peroxisomes searching cure for depression; and structural insights of resolves.

 

Dr. Y. K. Lahir, Visiting faculty

Dr. Y K Lahir got MSc and PhD degrees and DHE diploma from University of Bombay (now university of Mumbai). Currently he is visiting faculty, Department of Biophysics, university of Mumbai, teaching MSc I & II students. Visiting faculty, Department  of         Biological        Science, Biological/chemical sciences, NMIMS, SCHOOL OF SCIENCE, (Deemed to be university), Shri C. B. Research, Vile Parle (w), Mumbai. Visiting faculty o, Department of Environmental Sciences, Institute of Science, (Autonomous institute), Mumbai, He has been teaching for 43 years.

 

Dr. Pushpa Mishra, DST INSPIRE Faculty

Dr. Pushpa Mishra has joined department of Biophysics in 2017. She had finished her M.Sc. in Chemistry from Indian Institute of Technology Delhi (2009) and PhD from Tata Institute of Fundamental Research, Mumbai (TIFR) in structural Biophysics (2015). After then she moved to National Institute of Health (NIH), Bethesda, MD, USA for her Postdoc (2015-2017). Her area of research is Structural Biophysics using Nuclear Magnetic Resonance spectroscopy and development of Magnetic Resonance methods to get deep insights into the structure and function of bio-molecules. Her research interests are in understanding mechanism of action of Bcl-2 family of proteins in apoptosis. Her aim is to learn how pro-apoptotic proteins such as Bax and Bid and anti-apoptotic proteins such as Bcl-xl perform their actions in cytosol and mitochondria. Bax which is a major regulator in apoptosis, translocate from cytosol to mitochondria which subsequently initiates cascade of events and eventually cell death. How this translocation does initiates. How these proteins do behave in stress environment. She is also working on development of novel nanoparticle-apoptotic protein (Bid, Bcl-xl, and/or Bax) drug delivery systems. She has received several travel awards from DST, ICMR and TIFR to attend several international conferences such as ENC, ICMRBS, EUROMAR. She is also recipient of prestigious “Ranbaxy Research scholar award 2013 from Ranbaxy Science Foundation, Gurgaon, India.

 

Dr. Bipin Khade, Asst. Professor

Dr. Bipin S Khade, received a Masters Biophysics from Dr. Babasaheb Ambedkar Marathwada University Aurangabad and PhD in Nano-Biophysics from University of Mumbai. He was awarded Research Fellowship from University Grants Commission (UGC), New Delhi. He is presently Assistant Professor at Department of Biophysics University of Mumbai. His research work focuses on synthesis of metal nanostructure form biological, chemical and physical methods. His interests are to find out structure and functional aspect of digestive, immunoglobulin and carrier protein for target drug delivery application using development of Nano-Vehicle using biophysical approaches. He has published his research work in Journal of Luminescence, Journal of Nanoparticles Research and Journal of Inorganic Biochemistry; he also published 03 Indian Patent regarding synthesis of nanostructure and development of Nano-KIT.

 

Dr. Jessy Mariam, Asst. Professor

Dr. Jessy has obtained her PhD in Biophysics from Department of Biophysics, University of Mumbai. She was awarded the DST-INSPIRE fellowship (2010- 2014) for her doctoral tenure. She obtained her Bachelor’s degree in Microbiology, Biotechnology and Master’s degree in Biophysics from University of Mumbai. She worked as a postdoctoral fellow for four years at IIT Bombay. She is an awardee of DBT- Research Associateship, 2015-2018. Her research interests include nanobiophysics, protein-nucleic acid dynamics and fluorescent probes to study biomolecules. Currently she is an assistant professor at the Department of Biophysics.

 

Dr. Mrunal Ashtekar, Asst. Professor

M.Sc. in Biophysics ,Ph.D. in Biochemistry with the topic ‘ study of Immobilized /modified fungal enzymes’, has overall 14+ Yrs. of experience including Teaching, Lab work, Research work in variety of techniques such as UV visible spectroscopy, Gel electrophoresis, X-ray crystallography, microcalorimetry, Atomic Force Microscope, FTIR, Raman, SPR, fluorescence microscopy, protein analysis etc. Experienced biochemists who want to work in a hi-tech laboratory’s, Proficient with Soft skills covering – Time Management, Problem-solving, Critical- thinking and analytical skills. Good and thorough attention to detail, Excellent Interpersonal skills and a good team player

 

Dr. Swati Singh, Visiting faculty

Dr. Swati Singh, has completed M.Sc. in bioinformatics from Integral university (2010), Lucknow, and she completed her PhD (biotechnology, specialization: Bioinformatics) from Amity University, Lucknow, Uttar Pradesh in 2016. Currently she is working as visiting faculty in department of biophysics, University of Mumbai and department of Botany K J Somaiya College of Science and commerce. Dr. Swati was worked as DST-INSPIRE senior research fellow in department of Biochemistry, University of Lucknow (2014-2016).

 

POSTDOCTORAL FELLOWS

Dr. Neha Kumari, M.Sc., Ph.D.

D. C. Kothari Post-Doctoral Fellow

E-mail:nehanicky@gmail.com nehakumarimu@gmail.com

A highly motivated and hardworking individual with diverse experience from proteomics to nanotechnology. Offers strong analytical and problem-solving attitude as observed from PhD and post-doctoral research. Effective communicator, adaptive learner and trustworthy team player. Though, a gap of six years has not stopped her from doing research as evident from her research and review articles. Focus of current research is targeted drug delivery using nanoparticles albumin conjugate as a carrier. During PhD, expertise in proteomics, protein biochemistry, protein-protein interaction, polyclonal antibody development, immunolocalization, biochemical and biophysical characterization of protein are well evident with several publication. One year of teaching experience in Mumbai University has compliance her for teaching too. Currently, over two years of post doc research work is published in high impact journal and two articles are under preparation. A spearheaded continual improvement process across research is well evident. Overall, impressive records of accomplishment of doing independent research, excellent relationship with seniors, colleagues and juniors as well as external organizations are well reflected.

 

Dr. Anusri Bhattacharya, M.Sc., PhD (IIT Bombay) Post Doc. Fellow

Email: anusrib@gmail.com

The focus of my research is to decipher the role of centromeric protein, Scm3 in regulating the assembly of specialized nucleosome through NMR spectroscopic studies and other biophysical studies. Suppressor of chromosome mis-segregation (Scm3) has been known to play a regulatory role in the assembly of the centromeric nucleosome in S. cerevisiae. It acts as a chaperone to the histone variant, Cse4 in yeast and assists in its migration to the nucleosome. Scm3, Cse4 and histone H4 are necessary for the in vitro reconstitution of a heteromeric complex and conserved core of Scm3 is required for chromatin assembly. Therefore, I aim to study the solution state structure and dynamics of full length Scm3 by Nuclear magnetic resonance (NMR) spectroscopy. This will open avenues for the interaction studies of Scm3 with Cse4 and other histone components. Further, several biophysical techniques (circular dichroism spectroscopy, fluorescence spectroscopy, isothermal titration calorimetry, surface plasmon resonance, dynamic light scattering) will be done to acquire information about the intrinsic nature of the protein and study its interaction with its binding partners.

RESEARCH FELLOWS

Mr. Vinod Deomani Jaiswal, PhD scholar, JRF-CSIR NET

 Email id: jaisyvinod@outlook.com

 Research interest: My project involves designing nano- based targeted drug delivery systems that could acts as a cellular probe for diagnostic and therapeutic purposes. My study involves physico- chemical characterization of these drug delivery systems and detailed understanding of the interaction between the drug and the drug delivery systems. In addition to this I am also probing the structural changes of the protein based carrier systems; stability and kinetics of drug within the conjugates

 

Mr. Manik N. Waghmare, PhD scholar, JRF-DST PURSE

Email id: waghmare.manik70@gmail.com

Research interest: My research focuses on  understanding the mechanism of interaction and characterization of protein-nanoparticle conjugates (endogenous and exogenous protein) using extensive biophysical techniques. Further, I have defined to study the physico-chemical properties such as biocompatibility, stability, surface activity, partition coefficient, dissociation constant, and in vivo studies. The aforementioned parameters would help to design and develop nanoconjugates for targeted drug delivery application.

 

Ms. Dhanashri Pangam, PhD scholar, SARTHI fellow

Email id: pangam2208@gmail.com

Research interest: Being a common threat of rural area, snake envenomation is still one the most neglected human health problems. This problem ensues due to the lack of knowledge of first aid measures, complete reliance on tradition practices and myths, lack of medical emergency facilities, untimely administration of appropriate anti-snake venom (ASV) dose and finally non-specific reactions of ASV. Treatment with Anti snake venom (ASV) is lifesaving, but very risky, because the serum which being used as antivenom is heterologous (produced in different species) and may cause sensitivity reactions in some patients. My project explores the bioactivity of nanomaterials towards venom. Nanomaterials are being used since ancient times in various fields. They also show spectacular interactions with biomaterials. Here we have used silver, gold and zinc nanomaterials against Cobra and Viper venom. Antivenom activity of these nanomaterials is being assayed using in vitro (phospholipase, protease, acidimetry assay and whole blood clotting test) as well as in vivo (chicken egg assay) analysis.

 

Ms. Niyati H. MudliarPhD scholar, GATE Qualified

Email-id: niyatimudliar@gmail.com

Research interest: My project is mainly based on developing sensors for an important biomolecule, Heparin. Apart from its biological significance that is imparted naturally to the blood, Heparin remains the most widely used anticoagulant administered during surgery as prevention towards thrombosis. However, heparin overdose may lead to certain post-surgical complications such as hemorrhages, Heparin-induced thrombocytopenia, etc. which makes it inevitable to monitor the level of Heparin during and after surgery. In my current project, we aim at developing molecular rotor based fluorescent sensors for Heparin, which shall be simple, economic, selective and sensitive, in contrast to the currently practiced indirect methods.

Mr. Mahesh Samant, PhD Scholar: Area of Research: Biophysical understanding of protein-nanoparticles interaction

 

Mr. Suraj Singh, Research fellow (under DST Inspire faculty)

Email id: ssurajcxs@gmail.com

Research interest: Apoptosis is the natural process by which body gets rid of unwanted cells. This is done via intrinsic or extrinsic pathway, mainly main focus is on intrinsic pathway of apoptosis as defect in this pathway leads to cancer or uncontrolled cell growth Bid, Bax and Bcl-xl are main regulators of apoptosis where bcl-xl is anti-apoptotic and bid and bax are pro apoptotic proteins. So, in order to understand apoptosis, the in vitro study on effect of therapeutic drugs and stress such as UV on the structure and function of this proteins also the effect of lipids can be useful to understand their function in the cell and to prevent or cure cancer.

 

ADMINISTRATIVE STAFF

Mrs. Suchita M. Patil
B.Sc. (chemistry, Lab Assistant)
Email id: ssssmpatil@gmail.com

Miss. Shraddha Santosh Shedge
(junior cleark)

Mr. Anil Ghadshi
(peon)

FACILITIES

INFRASTRUCTURE AND LEARNING RESOURCES

  • Departmental building

University Department of Biophysics is a single storey building with a grooved semi hexagonal geometry with end to end corridor running throughout the building. At one end of the building Department have HOD office and Seminar/Teaching Hall and on other end one can find M.Sc. Training/Preparation laboratory, Lab 2, Lab 3. Between the extremes ends the middle section of the building has Department Office, Library, Gamma Irradiation laboratory and Lab 1. At the entrance Department has a waiting area facility. Waiting area has a provision of seating arrangement, Departmental Information, Notice Board containing upcoming events and media coverage, etc. Department has given a prime importance to the security affairs keeping entire department under surveillance 24 x 7. Building is totally surrounded by nature which enhances its beauty and thus makes it unique among other department in the University.

  • Library

Library is an asset to an institution. Any University is rich because of its rich learning resources. University of Mumbai has a valuable collection of near about 7 lakh books, twenty thousand theses and dissertations, and thousands of periodicals and manuscripts.

In addition to the University Libraries (Rajabai Tower Library and Jawaharlal Nehru Library) Department of Biophysics has its own library which is composed of approximately 400 books including Reference books and Journals. Library also has a valuable set of PhD theses, Project Reports, Dissertations and Published Papers. The collection here is not limited to Biophysical books only. Because of the vastness and the interdisciplinary nature of the subject Department of Biophysics has special collection of Chemistry, Physical Chemistry, Life Sciences, Nano-biophysics, Radiation, Biochemistry, Physiology, Crystallography, Drug delivery, Protein Biophysics, Bioinformatics,Biostatistics, Ecology, Environmental Biophysics, etc. Access is made very feasible just by the recording entry in the library register file. Departmental library extends reading facilities to all post graduate students, PhD students, Post- Doctoral Student, Faculty members and Professors of Biophysics Department.

From the commencement of New Department Building i.e. in last ten years Department has procured books net worth of Rupees 13-14 lakh. Department with all its dedication has positively immobilised the received grant for the library set up. Department of Biophysics is sincerely promoting a high value.

  • Teaching Hall

Department has one teaching Hall measuring an area about 700 square feet with a capacity of 60 students. The teaching Hall is utilised for Tutorials, Seminars, Small and Large group teaching, invited talks and Journal Clubs lecture series and conducting Internal examinations. Educational delivery systems such as Over Head Projector (OHP), LCD Projector are effectively used under innovative teaching methodologies in addition to the traditional teaching facilities (white board marker). The teaching Hall is very well equipped with e-learning facilities to be used in the educational delivery systems such as Bio- informatics online and offline software. 24 hours Wi-Fi facilities in the classroom enables students to use their personal laptops for teaching learning purpose. Apart from these facilities the walls of the lecture halls are mounted with the posters of the scope and areas of Biophysics, breakthroughs in the field of Biophysics and Nobel laureates in Biophysics, for motivation for Students. Department has certainly created a positive atmosphere for teaching learning facilities.

  • Department Office

An administrative activity is the backbone of any institution and therefore Administrative support is must for smooth functioning of the Department. Day to Day activities of administration involve work related to Record Keeping, billings, budgets, etc. Student enrolment register, Scholarship files, PhD registration files, Purchase files, Budget books, Mark sheet files, Conferences/Seminar record files, Finance and Account files, Repair and Maintenance records and other files have been systematically segregated. With such disciplined procedure it is indeed very helpful to present data to national bodies such as NAAC.

RESEARCH EQUIPMENT FACILITIES

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

RESEARCH

THRUST RESEARCH AREAS

Nanobiophysics, Nanomedicine, Molecular Biophysics, Radiation Biophysics

RESEARCH INVESTIGATORS

  • Dr. P. M. Dongre, Prof & Head, Department of Biophysics.
  • Nagraj Huilgol, Department of Oncology. Dr. Balabhai Nanavati Hospital,Mumbai
  • Unmesh Takalkar, Dr. Kodlikiri Hospital, Aurangabad.
  • Prof. B. S. Rao, Adjunct Faculty, Department of Biophysics.
  • Prof. A. V. Chitre, Adjunct Faculty, Department of Biophysics.
  • Prof. S. Sivakami, Adjunct Faculty, Department of Biophysics.
  • Dr. Avinash Kale, Adjunct Faculty, Department of Biophysics.
  • Dr. Y K Lahir, Adjunct Faculty, Department of Biophysics.
  • Dr. Pushpa Mishra, DST-INSPIRE Faculty, Department of Biophysics
  • Rajesh Shah, Life Force Trust, Mumbai
  • Dr V L Mathe, SPPU, Pune

 

RESEARCH COLLABORATORS

❖ Advanced Cancer Training and Education Centre, Kharghar, Mumbai

❖ Dr Kodlikiri Hospital, Aurangabad

❖ Haffkine Institute of Training and testing, Mumbai

❖ UM DAE Centre for Excellence in Basic Sciences

❖ Smt Savitribai Phule Pune University, Pune

❖ Photochemistry Laboratory, BARC, Mumbai

  • Life Force Trust, Mumbai

❖ Ashwamegh Biotech, Kopergaon, Dist. Ahmednagar

 

 

RESEARCH PROJECTS COMPLETED

 Projects supported by Mumbai University 

  • Interaction of nanoparticles with model biological system (Protein).
  • Image guided intensity modulated radiotherapy: A comprehensive dosimetry and radiobiological study.
  • Macromolecular crowding- a biophysical study of implication of volume exclusion effects on bimolecular complexes and them reconstitutes
  • Study of diffusion and permeability of nanoparticles through model biological membranes.
  • Structure-function properties of nanoparticles bound to biological active molecule in presence of UV radiation.
  • In-silico Molecular Docking and Virtual Pharmacokinetic Screening study of Psoraledin and its Derivatives as Phosphatidylinositol3-kinase inhibitors
  • Impact of microwave radiation induced heating on vitamins and proteins
  • Screening of antithrombotic property of some herbal compounds
  • Study of the electrical activity of human brain and heart of the subjects who practice meditation.
  • In vitro structure-function based assays of snake venom in presence of nanoparticles

 

Projects sponsored  by Govt of India 

  • Oxidative stress of cancer patients undergoing chemotherapy and radiotherapy treatment (BRNS, DAE, Government of India).
  • Development of Bioinformatics database for Radiomodifiers and make available through internet to user community (BRNS, DAE, Government of India)
  • Design and Development of packaging for Dry Electrodes for Bio-potential measurement and their clinical testing (DRDO, Government of India)

 

ONGOING RESEARCH PROJECTS 

Projects supported by Mumbai University

  • Physico-chemical aspects of nanoparticle- protein corona- relevance in targeted drug delivery.
  • Study of albumin-nanoparticle complex with model glycoprotein using biophysical approaches for targeted drug delivery
  • In vitro identification of nanoparticle for inhibition of snake venom activity

 

Sponsored Projects by Govt of India & NGO

  • Effect of UV and H2O2 stress on Bid and Bcl-xl apoptotic proteins (DST-INSPIRE)
  • Biophysical characterization of Homeopathic formulations (Life Force Trust, Mumbai)
  • Targeted drug delivery with albumin-nanoparticle-glycan conjugates. (Under UGC D.S.Kothari Post Doctorate fellowship )
  • Deciphering the role of Scm3 in the regulation of the specialized nucleosome in Saccharomyces cerevisiae. (Under UGC D.S.Kothari post doctorate fellowship)

 

Ph.D. AWARDED STUDENTS/THESIS SUBMITTED

Sr No. Student Name Topic Name Fellowship awarded Degree

awarded Year

Name of Supervisor
1 Ms. Jessy John A study of interaction of Nanoparticles with model Biological Systems  using Biophysical Approaches. DST- INSPIRE 2014 Prof PM Dongre
2 Mr. Dayanand Sharma Image guided intensity modulated radiotherapy: A comprehensive dosimetry and radiobiological

study.

2014 Prof PM Dongre
3 Priyanka Pal Macromolecular crowding- a biophysical study of implication of volume exclusion effects on bimolecular complexes and their reconstitutes DST- INSPIRE 2016 Prof PM Dongre
4 M.Venkatramanan Characterization of Flagellar associated protein 174 (FAP174) from the green chlorophyte

Chlamydomonas reinhardtii

DBT-SRF 2016 Prof PM Dongre
5 Mr. Bipin S Khade Investigation of structure function relationship of model protein in presence of metallic nanoparticle UGC- RGNF 2018 Prof PM Dongre
6. Mrs. Aditi Lohot A systematic study of the electrical activity of human brain and heart of the subjects who practice meditation. Non-Net May 2018 Prof PM Dongre
7. Mrs. Vrushali Hingane In vitro structure-function based assays of snake venom in presence of nanoparticles Non-Net May 2018 Prof PM Dongre
8. Mrs. Sharda Sawant A study of desmosomal and hemi- desmosomal adhesion junctions in neoplastic progression of human oral cancer using transmission

electron microscopy.

———— 2019 Prof PM Dongre

 

FINANCIAL SUPPORT FOR RESEARCH PROJECT

Sr No Title of Project                                      Investigator Funding agency Duration Total cost (INR)
1 Studies on oxidative stress of various cancer patients undergo Chemotherapy and Radiotherapy and to evaluate those as surrogate markers for immediate clinical response.

 

PI:  Dr P M Dongre

CI: Dr Nagraj Huilgol

DAE- BRNS 2008-2011 12,07,450

 

2. Development of Bioinformatics database for Radiomodifiers and make available through internet to user community

 

PI: Dr P M Dongre DAE-BRNS 2010-2013 7,96, 900/-

 

3. For Strength  research laboratory       – DST PURSE ( 1st  Phase) 2010-2013 ̴ 18,000,000
4. Design and Development of packaging for Dry Electrodes for Bio-potential measurement and their clinical testing

 

PI: Dr H  Muthurajan

CI: Dr P M  Dongre

DRDO 2015-16 9,74,000
5

 

Symposia/ conference Dr P M Dongre ICMR 2013-14 40,000
6 Symposia/ conference

 

Dr P M Dongre CSIR- 2013-14 50,000
7

 

Symposia / conference Dr P M Dongre DBT 2013-14 1,50,000
8 Symposia / conference

 

Dr P M Dongre DAE BRNS 2013-14 1,00,000
9

 

Symposia /conference Dr P M Dongre DRDO 2013-14 50,000
10 Symposia/ conference Dr P M Dongre Ministry of Environment science 2013-14 70,000
11 Symposia / conference

 

Dr P M Dongre NGO 2013-14 20,000
12 For Strength research laboratory

 

 

Dr PM Dongre DST PURSE

(2nd  Phase)

2016-2019 ̴65,00,000
13 Biophysical study of Homeopathy formulations Dr PM Dongre

Dr Rajesh Shaha

Life Force Trust, Mumbai 2017-18 1.54000
Total 2,73,15450

 

Finance support for strengthen laboratory & library

Sr No Agency Rs
1 UGC IX Plan 6,34,497
2 UGC XII Plan 1,53,234
  Total 7,87,731

 

Financial support from Mumbai University for Equipments, consumable, Books etc

Sr No Agency Rs
1 University of Mumbai ( 2008-2018) 16,875,0000
    16,875,0000

Fellowship Awarded for Research Scholar

 

Sr. No. Name of Agency Amount (INR), Approximate
1. DST-INSPIRE 14,43,000
2. DAE-BRNS 7,90,554
3. DBT-JRF 15,00,000
4. RGNF-UGC 9,12,000
5. Non-NET-UGC 1,174,800
6. DST-PURSE 5,84,000
Total: 6404354
Total     6404354

 

           

Total finance support for research and development activities  (2008-  2018):  Rs.  5,13,8 2535/

———————————————————————————–

RESEARCH PROJECTS OUTCOME

 

Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior and indispensable in many areas of human activity. Designing non-toxic nanomaterials and their conjugates requires an in-depth research to understand how these nanomaterials interact with biological systems like biomacromolecules (protein, enzyme, carbohydrate, lipid etc.), cells, cell membranes etc. So, the question becomes…how do nanomaterials transform / interact once they come into contact with biomolecules? This question has become increasingly important, especially as nanomaterials are developed for the biotechnology and nanomedicine fields. Therefore, the department is mainly focusing on understanding the mechanisms of interaction of nanoparticles with biological      systems (protein /enzyme /membrane /cells) using biophysical approaches and how they further impact the process of targeted drug delivery. We employ various biophysical tools such as fluorescence spectrophotometer, Raman spectrophotometer, FT-IR, Fluorescence Microscopy, UV Visible spectrophotometer, Fluorescence Microscope, Dynamic Light Scattering, Atomic Force Microscope (Bio AFM), Surface Plasmon Resonance Analyzer, single and 2- D gel electrophoresis etc. The output of the research projects conducted since 2009-10 by the department has been reflected in many national and international peer review index research journals with their citation numbers. We have been successfully able to establish how serum proteins and enzymes interact with various metallic and semiconductor nanoparticles. How their adsorption on the nanoparticle surface modulates the structure and function of the biomolecule. Further we have been able to characterize the hard and soft corona of these nanoparticle-protein conjugates and how the former corona enables efficient drug binding and biocompatibility. We have also been able to demonstrate nanoparticle behavior at the cellular level. A novel finding reported by us is ZnO nanosheets as radioprotectors during the event of cell division. A detailed investigation of nanoparticle-albumin- glycan conjugates that can potentially mediate targeted drug delivery in endothelial cells has also been reported. Using biophysical and biochemical approach we have also proved the inhibitory effects of silver nanoparticles against viper venom. Viper venom proteins were observed to compactly bind on the silver nanoparticle surface. Thus, diverse aspects of nanoparticle behavior, toxicity etc. has been extensively studied and published mainly to develop a targeted drug delivery system. Currently we are working on our above stated, well characterized  nanoparticle–biomolecule conjugates with an aim to develop stable drug delivery systems and formulations.

Due to the inherent and problematic side effects of current synthetic drug therapies there is an increased interest in developing and locating compounds which activate apoptosis, naturally. Prof. Pushpa Mishra, DST INSPIRE Faculty is working on Bcl-2 family of proteins which is a promising target for altering tumour cell sensitivity for apoptosis. Curcumin is a natural component in turmeric and is well-known for its pharmacological effects in preventing and fighting against many ailments and has been shown to decrease the rapid proliferation of a wide variety of tumour cells. However, to date, the mechanism by which curcumin exerts its cytotoxic effects in cancer cells is unknown. Motivated by reports indirectly linking the intracellular modulation of Bid and Bcl-xL, following curcumin administration to cancer cells, we set out to probe for intermolecular interactions of these proteins with curcumin. Using several biophysical techniques, most notably, fluorescence, circular dichroism (CD), and nuclear magnetic resonance spectroscopy (NMR), we have revealed binding interactions of curcumin with both Bcl-xl and Bid. This binding is observed to be hydrophobic in nature. We have furthermore shown that cellular stressors such as UV can induce structural change in these proteins. Interestingly, dependent upon the intensity of UV exposure, there is a gradual conversion of helices to β sheets in Bcl-xl while for Bid, this decrease in helicity coincides with an increase in turns. The manner in which these structural changes alter function is currently under investigation.

 

PUBLICATIONS

Research paper publications

Sr No Title & author of paper
1.  Niyati Mudliyar, Prabhat Singh and PM Dongre, A molecular Rotor Based Dual Ratiometric Sensor, Dyes and Pigments, 2020, Press (DYPI_2020_647)
2 Vinod J. P M Dongre, Biophysical interaction between silver nanoparticles-albumin interface and curcumin, Journal of Pharmaceutical Analysis, Press, 2020
3. Manik N. Waghmare  Tazeen S. Qureshi  Afrin N. Shaikh  Dr. Bipin S. Khade  Dr. C. Murali Krishna  Prof. Prabhakar M. Dongre, Functionalized Alpha‐lactalbumin Conjugated with Gold Nanoparticle for Targeted Drug Delivery, ChemistrySelect, 2020, 5:6, 2035-2049
4. An efficient J-aggregate based fluorescence turn-on and ratiometric sensor for heparin NH Mudliar, PM Dongre, PK Singh, Sensors and Actuators B: Chemical 301, 127089
5. Lahir, Y. (2019). Graphene and Graphene-Based Nanomaterials Are Suitable Vehicles for Drug Delivery. In Applications of Targeted Nano Drugs and Delivery Systems(pp. 157-189). Elsevier
6. Albumin nanoparticles conjugates binding with glycan-A strategic approach for targeted drug delivery, N Kumari, VL Mathe, PM Dongre, International journal of biological macromolecules

126, 74-90

7. Dongre, P. M., & Joshi, A. (2018). A systematic organization of bioinformatics database of radiosensitizers and radioprotectors. Journal of Radiation and Cancer Research, 9(2), 102.
8. Waghmare, M., Khade, B., Chaudhari, P., & Dongre, P. (2018). Multiple layer formation of bovine serum albumin on silver nanoparticles revealed by dynamic light scattering and spectroscopic

techniques. Journal of Nanoparticle Research, 20(7), 185.

9. Sawant, S., Dongre, H., Ahire, C., Sharma, S., Jamghare, S., Kansara, Y., & Gupta, S. (2018). Alterations in desmosomal adhesion at protein and ultrastructure levels during the sequential progressive grades of human oral tumorigenesis. European journal of oral sciences, 126(4), 251-

262.

10. Hingane, V. C., Pangam, D., & Dongre, P. M. (2018). Inhibition of crude viper venom action by

silver nanoparticles: A biophysical and biochemical study. Biophysics and Physicobiology, 15, 204-213.

11. Pal, P. D., Dongre, P. M., & Chitre, A. V. (2018). Volume exclusion influences in spectral characteristics of DNA-amino acids complexes. Vibrational Spectroscopy, 99, 137-145.
12. Y K Lahir, 2018 Review: Influence of nanomaterials on cellular stress and cellular response
13. Lahir, Y. K. (2018). Impacts of metal and metal oxide nanoparticles on reproductive tissues and spermatogenesis in mammals. Journal of Experimental Zoology, India, 21(2), 593-608.
14. Khade, B. S., Mathe, V. L., & Dongre, P. M. (2017). α-amylase binding to thermal plasma synthesized zinc oxide nanosheets: A fluorescence study. Journal of Luminescence, 187, 449-456.
15. Cover image, Volume 23 , Number 8, November 2017, Leading in Oral, Maxillofacial, Head & Neck Medicine
16. Mariam, J., Sivakami, S., & Dongre, P. M. (2017). Elucidation of structural and functional properties of albumin bound to gold nanoparticles. Journal of Biomolecular Structure and Dynamics, 35(2), 368-379
17. Sawant, S. S., Dongre, H., Ahire, C., Sharma, S., Kannan, S., Mahadik, S., & Vaidya, M. M. (2017). A nomogram for predicting the risk of neck node metastasis in pathologically node‐negative oral

cavity carcinoma. Oral diseases, 23(8), 1087-1098.

18. Jaiswal, V., Samant, M., Kadir, A., Chaturvedi, K., Nawale, A. B., Mathe, V. L., & Dongre, P. M.

(2017). UV Radiation Protection by Thermal Plasma Synthesized Zinc Oxide Nanosheets. Journal of Inorganic and Organometallic Polymers and Materials, 27(5), 1211-1219.

19. Influence of Meditation on Visual and Auditory Reaction Time in

 

Young Healthy Volunteers, Indian Journal of Physio Pharmacol, 2017; 61(2) : 100–106

20. Yogesha, M., Rao, V. G., Martis, E. A., Coutinho, E. C., Gohlke, H., Chidangil, S., & D’Souza, J. S. (2017). Structural features of FAP174, a MYCBP-1 orthologue from Chlamydomonas reinhardtii,

revealed by computational and experimental analyses. RSC Advances, 7(81), 51391-51402.

21. Yogesha, M., Rao, V. G., Martis, E. A., Coutinho, E. C., Gohlke, H., Chidangil, S., & D’Souza, J. S. (2017). Structural features of FAP174, a MYCBP-1 orthologue from Chlamydomonas reinhardtii, revealed by computational and experimental analyses. RSC Advances, 7(81), 51391-51402.
22. Y K Lahir, 2017 Impacts of Fullerene on Biological Systems, November 2017 DOI: 10.2174/2212707004666171113151624
23. Impacts of metal and metal oxide nanoparticles on embryos, Citation: Lahir YK. Impacts of Metal and Metal Oxide Nanoparticle on Embryos. Austin Endocrinol Diabetes Case Rep. 2017; 2(1): 1009.Austin Endocrinol Diabetes Case Rep – Volume 2 Issue 1 – 2017Submit your

Manuscript | www.austinpublishinggroup.com Lahir. © All rights are reservedAustin Endocrinology and Diabetes Case Reports

24. Impacts of metal and metal oxide nanoparticles on embryos.

Lahir YK. Impacts of Metal and Metal Oxide Nanoparticle on Embryos.

Austin Endocrinol Diabetes, 2017; 2(1): 1009.

25. Guru, A. D., Lahir, Y. K., & Mohite, V. T. (2017). Study on some biochemical aspects of alimentary canal of millipedes Harpaphe haydeniana (Wood). Journal of Experimental Zoology, India, 20(2), 789-794.
26. Mariam, J., Sivakami, S., & Dongre, P. M. (2016). Albumin corona on nanoparticles–a strategic approach in drug delivery. Drug delivery, 23(8), 2668-2676.
27. Pal, P. D., Dongre, P. M., & Chitre, A. V. (2016). Implications of Volume Exclusion: A Look at

Thermodynamic Perspective of DNA-Hemoglobin Complexes and Their Reconstitutes Under Macromolecular Crowding. Journal of fluorescence, 26(1), 355-362.

28. Y K Lahir, ROLE OF NANOMATERIALS IN THE DEVELOPMENT OF BIOSENSORS, G.J.B.B., VOL.5(2)2016: 146-163
29. Gurve, D., Muthurajan, H., Karnik, P., Deshpande, A., Srivastava, A. K., Mukhopadhyay, K., & Dongre, P. M. (2016, March). Novel algorithm for coherence level measurement using RR interval of ECG signal. In 2016 International Conference on Wireless Communications, Signal

Processing and Networking (WiSPNET) (pp. 2187-2191). IEEE.

30. Rao, V. G., Sarafdar, R. B., Chowdhury, T. S., Sivadas, P., Yang, P., Dongre, P. M., & D’Souza, J. S.

(2016). Myc-binding protein orthologue interacts with AKAP240 in the central pair apparatus of the Chlamydomonas flagella. BMC cell biology, 17(1), 24.

31. Tari, D., Haryan, S., Patankar, K., Jaiswal, V., Samant, M., Sivakami, S., & Dongre, P. M. (2016). A simple egg membrane model for understanding diffusion characteristics of nanoparticles and

amino acids. Available at SSRN 2783837

32. Y K Lahir, Application of time and length scale concept in biological systems, Biochem. Cell. Arch.Vol. 16, No. 2, pp. 231-237, 2016
33. Lahir, Y. H. (2016). Understanding the basic role of glycocalyx during cancer. Journal of Radiation and Cancer Research, 7(3), 79.
34. Lahir Y.K. Some Aspects of Interactions between Nanomaterials and the Cytoskeleton of Eukaryotic cells, January 2016, DOI: 10.23880/ACT-16000111
35. Y K Some Biophysical And Biochemcial Interactions Of Nanomaterials On Protein Oxidation In Biological System Report and Opinion 2016;8(7)
36. Shirsekar, P. P., Kanhe, N., Mathe, V. L., Lahir, Y. K., & Dongre, P. M. (2015). Interaction of zinc oxide Nanoparticles with human red blood cells. Bionano frontier
37. Lahir, Y. K. (2015). Lipid oxidation in biological systems: Biochemical, Biological and Biophysical aspects. Global JB B, 4, 224-233.
38. Kumar, L. Y. (2015). Role and adverse effects of nanomaterials in food technology. Journal of toxicology and health, 2(1), 2.
39. Lahir, Y. K. (2015). A dynamic component of tissues-Extracellular matrix: Structural, functional and adaptive approach. Biochem Cell Arch, 15, 331-47.
40. Lahir, Y. K. (2015). Lipid oxidation in biological systems: Biochemical, Biological and Biophysical aspects. Global JB B, 4, 224-233.
41. Kumar, L. Y. (2015). Role and adverse effects of nanomaterials in food technology. Journal of toxicology and health, 2(1), 2.
42. Mariam, J., Sivakami, S., Kothari, D. C., & Dongre, P. M. (2014). Bioactivity of albumins bound to silver nanoparticles. The protein journal, 33(3), 258-266.
43. Pant, M. P., Mariam, J., Joshi, A., & Dongre, P. M. (2014). UV radiation sensitivity of bovine serum albumin bound to silver nanoparticles. Journal of Radiation Research and Applied Sciences, 7(4),

399-405.

44. Pardeshi, P., Nawale, A. B., Mathe, V. L., Lahir, Y. K., & Dongre, P. M. (2014). Effects of zinc oxide nanoparticles on the hepatic tissue of chicken embryo: a histopathological approach. Bio Nano Front, 2, 176-180.
45. Pal, P. D., Dongre, P. M., & Chitre, A. V. (2014). “Is Macromolecular Crowding Overlooked?”- Effects of Volume Exclusion on DNA-Amino Acids Complexes and Their Reconstitutes. Journal of

fluorescence, 24(4), 1275-1284.

46. Bhogale, A., Patel, N., Mariam, J., Dongre, P. M., Miotello, A., & Kothari, D. C. (2014).

Comprehensive studies on the interaction of copper nanoparticles with bovine serum albumin using various spectroscopies. Colloids and Surfaces B: Biointerfaces, 113, 276-284.

47. Lahir, Y. K. (2014). Morphological aspects of intercellular communication. Bionano Frontier, 7(1), 03-17.
48. Lahir Y K, Morphological aspects of inter cellular communication, Bionano Frontier, 2014, 7(1): 03-11
49. Bhogale, A., Patel, N., Mariam, J., Dongre, P. M., Miotello, A., & Kothari, D. C. (2013, February).

Study of interaction of ZnO nanoparticles with human serum albumin using fluorescence spectroscopy. In AIP Conference Proceedings (Vol. 1512, No. 1, pp. 130-131). AIP.

50. Bhogale, A., Patel, N., Sarpotdar, P., Mariam, J., Dongre, P. M., Miotello, A., & Kothari, D. C. (2013). Systematic investigation on the interaction of bovine serum albumin with ZnO nanoparticles using fluorescence spectroscopy. Colloids and Surfaces B: Biointerfaces, 102, 257-264.
51. Dr P M Dongre, Effect on cognitive function from mobile phone use, Bionano frontier, Vol. 5. (1),2012
52. Dr P M Dongre et al, Impact of microwave radiation heating on vitamins and proteins, Bionano Frontier, Vol. 5. (1),2012
53. Sharma, S. D., Dongre, P., Mhatre, V., & Heigrujam, M. (2012). Evaluation of automated image

registration algorithm for image-guided radiotherapy (IGRT). Australasian physical & engineering sciences in medicine, 35(3), 311-319

54. Shelke, J., Meshram, G., & Dongre, P. (2012). SYNTHESIS OF 2-OXOQUINOLINE-3-CARBOXAMIDE OF AMPICILLIN AND AMOXICILLIN AS INHIBITORS OF PENICILLIN BINDING PROTEIN 1A OF

PSEUDOMONAS AERUGINOSA. Acta poloniae pharmaceutica, 69(4), 623-628.

55. Mariam, J., Dongre, P. M., & Kothari, D. C. (2011). Study of interaction of silver nanoparticles with bovine serum albumin using fluorescence spectroscopy. Journal of fluorescence, 21(6), 2193.
56. Sharma, D. S., Dongre, P. M., Mhatre, V., & Heigrujam, M. (2011). Physical and dosimetric characteristic of high‐definition multileaf collimator (HDMLC) for SRS and IMRT. Journal of applied clinical medical physics, 12(3), 142-160.
57. Yadav, A. A., Barote, M. A., Dongre, P. M., & Masumdar, E. U. (2010). Studies on growth and

characterization of CdS1− xSex (0.0≤ x≤ 1.0) alloy thin films by spray pyrolysis. Journal of Alloys and Compounds, 493(1-2), 179-185.

58. Meshram, G., Shelke, J., & Dongre, P. (2010). Synthesis, antibacterial study and molecular

docking of some acrylic amide derivatives of ampicillin and amoxicillin. J Pharm Res, 3(10), 2371-2374.

59. Khurana, R. R., Patel, V. V., Dongre, P. M., & Nagare, B. J. (2009) In-silico Molecular Docking and Virtual Pharmacokinetic Screening study of Psoralidin and its Derivatives as Phosphatidylinositol 3-Kinase Inhibitors. Trends in Bioinformatics 5(1 &2):163-178
60. Bansode, T. N., Dongre, P. M., & Dongre, V. G. (2009). Synthesis, antibacterial and antifungal

activity of 1, 3-di (2-substituted 10H-phenothiazin-10-yl) propan-1-one. Pharmaceutical chemistry journal, 43(6), 311.

61. Simple, Efficient Synthesis, Antibacterial activity and Molecular Docking Study of 3- (1Hbenzimidazol- 2-yl)-2-chloroquinolines Compounds
62. Shilpa Patil, P M Dongre , Silver Nano Particles Modified Chitosan Beads: An Improved Stability of Cellulase by Immobilization
63. Y K Lahir, Advances in Clinical Toxicology Some Aspects of Interactions between Nanomaterials and the Cytoskeleton of Eukaryotic cells Some Aspects ofInteractions between Nanomaterials

and the Cytoskeleton of Eukaryotic cells Advances in Clinical Toxicology, Advances in Clinical Toxicology, volume 1 issue 2

Book Chapters

Sr No                                                                                  Book Chapters
Dr Y K Lahir, Graphene

1           APPLICATIONS OF TARGETED NANODRUGS AND DELIVERY SYSTEMS Publisher: Elsevier Inc, October 2018

Dr P M Dongre, Title of Chapter: Gold Nanoparticle–Assisted Radiation Therapy

2           Title of Book: Radiation in Medicine and Biology, Edited by Pandit B. Vidyasagar, Sagar S. Jagtap, and Omprakash Yemul, Copyright © 2016 Pan Stanford Publishing Pte. Ltd.ISBN 978-

981-4745-92-5(Hardcover), 978-981-4745-93-2 (eBook) www.panstanford.com

Proceeding Papers

 

Sr No

 

Title of Paper

 

1

Bipin S Khade, V L Mathe, and P M Dongre, Kinetic study of α-amylase bound on Zinc oxide

nanosheet, (Conference Proceeding- International conference on Nanotechnology for Human Welfare- International 2018, Feb 2018, (ISBN: 978-93-80747-98-7)HV Desai college Pune

 

2

Manik Waghmare Bipin S Khade, and P M Dongre, Spectroscopic Study of Albumin Adsorbed on Silver Nanoparticles, Conference Proceeding International conference on Nanotechnology for Human Welfare

International, Feb 2018, ISBN: 978-93-80747-98-7, HV Desai college Pune

 

3

Vinod Jaiswal, P M Dongre               Biophysical characterization of albumin bound silver nanoparticles Conference Proceeding-International conference on Nanotechnology for Human Welfare-International 2018- Feb 2018, ISBN: 978-93-80747-98-7, HV Desai college Pune
 

4

S. Mahesh, K. Bipin, P.M. Dongre, Study of dynamics of Protein Nanoparticle complex in aqueous

medium using impedance spectroscopy, Conference Proceedings Journal of proteins and proteomics           National, 2015 ISSN 09758151, Journal of proteins and proteomics

 

5

P. Kaustubh, P.M. Dongre et al, An experiment study of passive diffusion of silver nanoparticles and amino acids through model biological membrane Conference Proceedings, Journal of proteins and proteomics, National 2015 ISSN 09758151Journal of proteins and proteomics
 

6

A. Bhogale, D.C. Kothari, P. M. Dongre Study of interaction of ZnO nanoparticle with human serum albumin using fluorescence spectroscopy, AIP Conference proceedings, AIP National

2013, 0094-243X (print) 1551-7616 (web), AIP Advances

 

Patents

Sr No. Name of Patent
 

1

Bipin S Khade, and PM Dongre, Teaching, training and learning kit for synthesis of silver and gold metal nanostructure using enzyme,(Indian Patent Publication Date: 07/09/2018, 201821031747).
 

2

Bipin S Khade, and PM Dongre, An enzymatic method for synthesis of silver nanostructures with various sizes and less time consuming,(Indian Patent Publication Date: 07/09/2018, 201821031761).
 

3

Bipin S Khade, and P M Dongre, An enzymatic synthesis of gold nanostructures with uniform size and less time consuming (Indian Patent Publication Date: 07/09/2018, 201821031770).
4 Human plasma proteins-GNP (Gold Nanoparticle) conjugate – An alternative novel polyvalent Anti Snake Venom (ASV).

Patent Application No. 202021011364 dated 17.03.2020

 

5         Silver nanostructure based sanke venom inhibitor (progress)
6 Crystal for storage of biomaterials (in Progress)

INNOVATION & AWARDS 

Research, Innovation and Extension 

Digitization of bioinformatics database of radiosensitizers and radioprotectors 

Radiotherapy is regarded as one of the most important therapeutic modalities for the treatment of malignant lesions. This field is undergoing rapid advancements in the recent times. With the use of radio-sensitizing and radioprotective agents, the course of radiotherapy  has improved the sensitization of tumour cells and protection of normal cells, respectively

Radiosensitizers makes tumour cell more sensitive to radiation therapy which increase the effectiveness of cancer treatment where radioprotectors are the compounds that reduce the damage/ spare normal tissue. Several of these compounds have been studied using appropriate biological model system and their efficacy is reported in literature. The literature of these compounds is highly scattered and it is essential to have all this information on a single platform which will further help in improvement in radiotherapy treatment.

Hence, department has developed bioinformatics database of radiosensitizers and radioprotectors using information available in PubMed, scientific journals and other scientific sources. The collected information of these compounds is systematically organized on a single platform where user can browse typical information of the compound pertaining to mainly structural features, radiobiological aspects, biological targets, clinical trials, pharmacological aspects, toxicity etc. The direct link of these compounds is available on University of Mumbai web portal (www.mu.ac.in) / http://bioph.mu.ac.in/Welcome/ as well as Department of Biophysics web portal. This comprehensive database will be useful for clinicians, researchers and radiation workers etc. Along with this exhaustive exercise, we have invited feedback from users for further improvement or revision of this bioinformatics database. Similarly interested researcher, clinician can be uploaded his/her experimental data (peer reviewed).

Finance Support: Board of Research in Nuclear Sciences, Department of Atomic Energy, Govt of India

Nanostructure based snake venom inhibitor 

Snake bite is one of the most important public health problems worldwide, specifically in tropical countries. It is a common occupational hazard mainly in rural areas. There is significant morbidity and mortality reported worldwide. In India near about 52 thousand morbidity reported per year. At present there is no reliable treatment established due various physiological/ biochemical problems.

Snake venom is a complex mixture of various biologically, pharmacologically active  proteins and polypeptides. The current treatment available        for snake bite  is intravenous administration of anti-snake venom (ASV) which neutralizes snake venom. ASV is the polyvalent antibodies manufactured by using surrogate animals   (e.g. Horse).  These animals are immunized with the snake venom and then antibodies are collected from blood and purified. Treatment with Anti snake venom (ASV) is lifesaving but very risky and may no bet safe sometimes and may cause sensitivity reactions in patients (chills,   nausea and fever, hypersensitivity or anaphylactic shock). Hence there is a need to focus on alternative treatment considering the limitation of available treatment. In this research work, Silver/ gold nanostructures were used as potential inhibitors against snake venom. We have shown that action of venom is reduced up to 95% using these nanostructures. The lyophilized cobra and viper venom were used. This study has been published in peer reviewed Journal of  Biophysics  and   Physicobiology  ,  Japan. The results obtained are promising and can be used in future development of anti-snake venom inhibitor. This is primitive step towards the development of nanoparticles-based snake venom inhibition therapy. Department of biophysics is planning to study on animal models like mice for further development.

Teaching, Training kit for nanostructure preparation 

To train the students (high school, graduate, post graduate, research scholar etc) in the field of nanoscience and nanotechnology, we have developed teaching, training kit for synthesis of nanostructures (gold and silver). The kit provides desired chemicals/ constitutes, from which the students can easily prepare these nanostructures by following the given simple protocol. A major advantage of this kit eliminates sophisticated equipment’s and other expenditures.

Key features:

  1. First time will be introduced in educational system
  2. Simple, effective & economical kit for training, for understanding synthesis of nanostructures
  3. Minimum requirement, eco-friendly, customized and time saving
  4. Useful to high school, Jr & Sr College students

 

 

Crystal for cell / biomolecules storage

Storage / preservation of cells is extremely important to ensure that quality is maintained before usage of cells. Several industries such as the food, pharmaceutical and horticultural industries require an extensive use of various types of cells. Hence there is a requirement to preserve cells so that they can be used either directly or for further research at the appropriate time. In order to preserve these cells, expertise from a variety of disciplines including but not limited to engineering, biology, biotechnology, cryobiology etc is required to design protocols that enable the development of precise and reliable preservation methods. There are many methods that are used today to preserve cells such as cryopreservation, hypothermic preservation, vitrification, freeze drying etc. All these methods are having advantages, disadvantages and several limitations.

Our research team has developed a simple and innovative technique where cell / biological materials (DNA) can be preserved for longer time. Its unique crystal that can preserve cell longer time without providing nutrients, its cost effective, novel and simple. Not much expertise is required. Testing of this technique, experimentation and data collection / validation are in progress.

Teaching training membrane model for understanding diffusion characteristics in biology 

Diffusion is an important phenomenon that occurs in living system for carrying out various biological activities. This has been quantitatively described using mathematical models and proved experimentally. The outcome of these studies has been used for designing the experiments in vivo and vitro .The simplest mechanism by which molecules can across the membrane is passive diffusion. During passive diffusion, a molecule simply crosses the membrane and enters the aqueous solution at the other side of the membrane.

We have developed a simple biological membrane model for understanding diffusion characteristics in biology. The chicken egg shell has been used and prepare as membrane model to perform passive diffusion. It diffusion has been performed for Silver Nanoparticles and amino acids against gravity, towards gravity and lateral state. This membrane has been systematically characterized with the help of X-ray Scattering and Scanning Electron Microscopy. This model is being established at large scale level.

 

ACHIEVEMENTS/AWARDS/HONORS 

FACULTIES 

Dr. Prabhakar Dongre

Prof & Head, Department of Biophysics University of Mumbai

  1. Best faculty of the year awarded by Computer society of India, for the funded research – either Govt / Industry funded research projects (2018-19)
  2. Editor’s choice best research publication award by the Biophysical Society of Japan 2018-19
  3. Best Academician & Research Award by Manutius Marathi Mandal, Mauritius, May 2017.
  4. Invited by Department of Science and Technology for Noble Lecture series India 2018
  5. National committee member of International Union of Pure and Applied Biophysics (2012-16)
  6. Vice President of Indian Biophysical Society (2013-18)
  7. State Level    Award  by Bharatmata Bhauddesia Sanstha, Naldurg, Ta Tuljapur Dist. Osmanabad for outstanding work in education, Research and Training (2010).
  8. Outstanding service at Nanded flood Relief Camp during July-Aug. 2005, Awarded by Rotary Club of Latur.
  9. Best teacher award-University of Mumbai 2019-2020

 

M.Sc. and Ph.D. Students 

  1. Venkatramanan G. Rao (PhD Scholar), DBT- Senior Research Fellow
  2. Jessy Mariam, ( PhD scholar, 2008-14), DST INSPIRE fellowship, New Delhi
  3. Bipin S Khade (PhD student), RGNF.UGC XII plan
  4. Priyanka Pal, (PhD student) DST INSPIRE fellowship. New Delhi
  5. Mugdha Dhurandhar (MSc Student 2015-17), DST-INSPIRE, New Delhi, India
  6. Vrushali Khedekar ( MSc Student 2015-17), DST-INSPIRE, New Delhi, India
  7. Zehra Haider (MSc Student, 15-17), Scholarship through NGO
  8. Second prize for best research paper presentation in International Conference on Nanobiotechnology: An Interface between Physics and Biology, Jamia Millia Central University, New Delhi, in Dec 2-4, 2010. Jessy Mariam a Ph. D scholar had presented the paper.
  9. Bipin Khade, MH-SET (2015), CSIR-NET (2016)
  10. Bipin Khade Best research paper presentation award, IISER Mohali, March 2017
  11. Best paper presentation award Metalions, NEERI.
  12. Suraj Singh, Silver medal Avishkar 2017
  13. Manik Waghmare, Silver medal at Avishkar 2017-18 final University Round
  14. Vinod Jaiswal, Best research paper award- “International conference on Nanotechnology for human Welfare”.
  15. Vinod Jaiswal- NET    (CSIR-UGC 2018) Qualified
  16. Prasad Kapkar-NET (CSIR-UGC 2018) qualified
  17. Prasad Kapkar MH-SET (2018) qualified
  18. Dhanashri Pangam, Silver medal at Avishkar 2018-19 final University Round
  19. Dhanashri Pangam, PhD scholar, SARTHI fellow, 2019
  20. Vinod Jaiswal, University Gold medal-Avishkar 2019-2020
  21. Vinod Jaiswal, Innovation award by Nehru Science Centre, 2019-2020
  22. Vinod Jaiswal, Inter-University Gold medal-Avishkar 2019-2020
  23. Tazeen Qureshi M.Sc Student DST-INSPIRE award 2020

 

——————————————————————————————————————-

STUDENT SUPPORT & PROGRESSION

Financial Assistance

  • Scholarships:
    • National Merit Scholarship
    • GOI merit scholarship
    • Merit scholarship is also available of the University of Mumbai.
    • Earn and learned scheme
  • Study Tour: The Department organizes study tour for the students to visit National Research laboratories and R & D Industries laboratories in India.
  • Participation in conferences & Avishkar: Sc & PhD students are highly encouraged to attend national and international conferences and present their research work. It provides them a platform to interact with eminent scientists from India as well as abroad. Every year students from the department participate in the annual conference organized by Indian Biophysical Society (IBS). Students also participate actively in the inter-university competition like Avishkar. The department has bagged Avishkar awards continuously in the last four years. 
  • Project work: Department also helps Post graduate students in designing hypothesis, research problem through regular brainstorming session and executing their research work in the department. Apart from this they are guided in publishing their research work in reputed peer reviewed journals.

ALUMNI STATUS

PLACEMENT FOR HIGHER STUDIES

 

Sr No.    Name of student

 

NAME OF INSTITUTE

 

Academic Year

1.            Shruti Nimkar PhD, New Zealand 2004-05
2.            Ameya Sathe Post Doctorate – IISER Pune 2005-06
3.            Richa Singhal PhD, Kentucky University, US 2006-07
4.            Aditya Rao PhD, US 2006-07
5.            Shailu Laxman PhD, US 2006-07
6.            Sweta Parab PhD, NIRRH, Mumbai 2006-07
7.            Reshma Pandit PhD, KEM, Mumbai 2006-07
8.            Dipesh Jadhav NCL, Pune 2008-09
9.            Kartik Bane PhD EMBL UK 2008-09
10.          Rahul Jawale PhD Dept. of Biophysics, University of Mumbai 2008-09
11.          Anwesha Laha PhD, University of Lousville, USA 2009-10
12.          Amruta Joshi PhD, Dept. of Biophysics, University of Mumbai 2009-10
13.          Aditi Lohot PhD, Dept. of Biophysics, University of Mumbai 2009-10
14.          Pialy Chatrjee PhD, Haffkines Institue 2009-10
15.          Chaitanya Giri PhD, Max Plank Institute, Germany 2010-11
16.          Priyanka Pal PhD, Dept. of Biophysics, University of Mumbai 2011-12
17.          Pravin Bhise PhD, University of Mumbai 2011-12
18.          Ankita Balsaraf PhD, US 2011-12
19.          Vaibhav Patil PhD, Ireland 2012-13
20.          Nitish Kunte Research Fellow, ACTREC, Mumbai 2012-13
21.          Tushar Rashkar PhD , IIT-Mumbai 2012-13
22.          Sachin Ghag NIRRH, Mumbai 2013-14
23.          Shalaka Kadam NIRRH, Mumbai 2013-14
24.          Kaustubh Patankar PhD, ICT, Mumbai 2013-14
25.          Mahesh Samant PhD, Dept. of Biophysics, University of Mumbai 2013-14
26.          Sagar Khawenekar PhD, Switzerland 2013-14
27.          Monika Henry Research Fellow, IISC, Bangalore 2014-15
28.          Samuel Mangham Research Fellow, CCMB, Hyderabad 2014-15
29.          Surbhi Abhyankar RA, KEM, Mumbai 2014-15
30.          Manish Narkar Research Fellow, Haffkines Institute, Mumbai 2014-15
31.          Aditya Narvekar Research Fellow, IISER, Bhopal 2015-16
32.          Yojit Sharma Research Fellow, IISER, Kolkata 2015-16
33.          Nitin Kunthe IRELAND 2015
34.          Viabhav Kale IRELAND 2015
35.          Monica Henry IISc, BANGLORE 2016
36.          Kaustubh Patankar ICT, MUMBAI 2016
37.          Mahesh Samant BIOPHYSICS, MU 2016
38.          Sagar Khavnekar MAX Plank Germany 2017
39.          Tushar Rashkar University of Hamburg 2016
40.          Samual Mangam CCMB-HYDERABAD 2016
41.          Manik Waghmare BIOPHYSICS, MU 2017
42.          Yojet Sharma TIFR, Mumbai 2017
43.          Vinod Jaiswal BIOPHYSICS, MU 2017
44.          Manik Waghmare BIOPHYSICS, MU 2017
45.          Aditya Narvekar ICT, MUMBAI 2017
46.          Mugdha Dhurandhar NCBS, BANGALORE 2018
47.          Vrushali Khedekar NCBS, BANGALORE 2018
48.          Zehra Haider NIMHANS, BANGALORE 2018

 

ALUMINI FEEDBACK

Dr. Rekha Bajaj

Destiny landed me into the field of Biophysics by chance way back in 1986 when it used to be conducted at Cancer Research Institute, Parel. I completed my M.Sc. in Biophysics in 1988 and was offered a scholarship to go to Germany on a 1 year Project in NMR imaging, however I could not avail of it due to personal reasons. Biophysics showed me the beauty of seeing things through the interdisciplinary lens which benefited me and my students, when I became a Science teacher. I emphasized my students to analyse the interdisciplinary nature of all 3 sciences and Maths and I could see the excitement when they had their own Eureka moments while discovering unique patterns and relationships in nature. I have taught for many years, written many books on Science and now train Teachers to teach Science and I credit my foundation in Biophysics for honing my creativity and innovative domains and my success as a Teacher. Biophysics helps you analyse every aspect in depth and think out-of- the-box. I wish all Science teachers should at least have a background of one of the interdisciplinary subjects like Biophysics.

Dr. Richa Singhal, M.S., Ph.D.

I am Postdoctoral Associate, Department of Medicine, University of Louisville. I started my scientific pursuit with a Bachelor in Biotechnology. The natural evolution was to pursue my Masters in a field, which embodies both the biological structure of the cells and the physical laws governing them- BIOPHYSICS. The remarkable aspect that drew me towards this subject is its extension of molecular biology to the areas of computational and instrumentation techniques, and modern physics. The primary focus of the course was on the revelations of molecular structures which provided me with fresh insight into the way molecules work, particular in the development of biological systems and initiation of disease and disorder in the system. What stayed with me was the role played by the bio-molecular structure in information processing and signal transduction pathways within the cell. Biophysics course strengthened my interest in research, and I graduated with a Ph.D. in Biology with research in the field of plant biotechnology, biochemistry, molecular genetics, and bioinformatics. I am presently working as a postdoctoral associate at the Department of Medicine at the University of Louisville and involved in various projects broadly encompassing epigenetic modifications, proteomics, metabolomics, alcoholic liver disease, HIV and human microbiome research. To date, I use both fundamentals and recent developments in BIOPHYSICS in my medical research.

 

Dr. Sweta Parab, Ph.D.

The vastness of biology has always intrigued me. My quest in true sense started while pursuing my Bachelor’s degree in Microbiology, learning the living of microscopic organisms. Enrolling for Master’s program in Biophysics was an opportunity of gaining a new perspective in the field of biology. The coursework helped me understand the true essence of Biophysics. It helped me nurture my inquisitive mind and my interest in research. I have completed my Ph.D. in Biochemistry studying the role of reversible acetylation of alpha-tubulin in sperm motility at National Institute for Research in Reproductive Health (ICMR), Mumbai. At present I am a post- doctoral fellow at Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute-Cleveland Clinic, Cleveland, USA.

 

Mr. Prathamesh Pandurang Shirsekar

I, Prathamesh Pandurang Shirsekar, MSc Pass out batch 2014, working in the area of Biomedical Instrumentation (4 Years) as an application specialist with Bioscreen Instruments. Biophysics is branch of pure science where an individual can learn and make their basics strong on molecular mechanism of an organism, it’s relation with the thermodynamic properties and basic principles of molecular detection system through instrumentation. In short it allows understanding and detecting the biological activities on the basis of Law of Physics. Biophysics also deals with Nanotechnology and its application in drug delivery which plays major role in safe and accurate drug delivery to its target site. Biophysics allows an individual to explore themselves across multiple dimensions in the field of Pharma, research and physiology. Hence, it allows to mould yourself as per the requirement of any Biological and Biomedical instrumentation field and gives better chance to sustain in it. Biophysicist can work in Pharmaceuticals and biomedical instrumentation companies, hospitals, universities and research centres which give a wide area for job opportunities. Hence, Biophysics could be a best opportunity to define your future path.

Mr. Kaustubh Patankar

Biology has astonishing beauty embedded within it. It has been a reason of enthusiasm to mimic it in more and more sophistic manner. To mimic any kind of system one should have a thorough and deep knowledge about it. It is not possible to engrave or recast biological mimicry without knowledge of molecular machines driving it. In order to make this giant task one should be familiar with molecular symmetry; deep knowledge of high-resolution spectroscopic tools, high throughput imaging system, algorithms, computational modelling and list is endless. This seems to be a nail-biting task but aura of biophysics encloses of all these techniques. Biophysics is an interdisciplinary subject in which its nodes to all of the super speciality techniques those are evolved due to revolutionary characterization techniques and instrumentation. Biophysics explore wide range of area such as enzyme biophysics ,molecular motors, electrochemistry, photochemistry, redox chemistry, supra- molecular chemistry, nanotechnology, etc. Biophysics has endless opportunity. Biophysicist has to mark his focus with use of advanced instrumentation and characterization techniques to prove certain biochemical or biophysical phenomenon. I thank Prof. P. M. Dongre and his multi-speciality team for giving opportunity to me to take fist booster dose of biophysical horizon.

Mr. Sachin Anil Ghag

I am a Graduate Research Assistant, Department of Physiology, Southern Illinois University Carbondale, Illinois, USA. I feel proud to have post graduated from Department of Biophysics, University of Mumbai. I joined this department because of two reasons. First, Department has excellent research lab facility. Second, the syllabus of course is designed according to current research, textbooks and literature. Teaching faculty is competent professionally. During the 2 years stint of master degree, I have greatly enjoyed the process of building depth of my knowledge. I have earned adequate professional skills to work independently. Young researchers in the department were influential in ascertaining my confidence in pursuing research. International conferences and guest lectures organized by the department gave me a great opportunity to interact with scientists and students in the same field. A recommendation letter from Head of the department Dr. Prabhakar Dongre helped me secure a full-time job as research fellow at National Institute for Research in Reproductive Health. He also encouraged and guided me to pursue higher education in USA’s universities. I am overall happy and I would love to work for this department if given a chance.

Ms. Monica Henry

It has always been my passion to explore the Creator’s beautiful creations. The pursuit of such a desire led me to complete my BSc in Physics. I, then, joined theDepartment of Biophysics to pursue MSc in Biophysics. The best part of it was the interdisciplinary nature of the course, and learning from experts of different fields. This widened the horizon of Science to me. Learning Biophysics here has fostered the right environment to pursue my research ahead. I am currently  doing my PhD in Neuroscience in Molecular Biophysics Unit, IISc, Bangalore.

 

Ms. Surabhi Deepak Abhyankar

I am a Graduate student of Indiana University, Indiana, USA. Department of Biophysics is committed to high standard of education. Being master student, I hardly knew what to expect from teachers and the course work. But eventually I came to know, Biophysics is an amalgamation of Biology and Physics. Being a Microbiologist, I was very enthusiastic to learn new things, techniques and transform my mindset into research-oriented learning. The department of Biophysics encouraged me to explore other research areas and I got an opportunity to work in National Institute for Research in Reproductive Health and King Edward Memorial Hospital, Mumbai. The knowledge which I gathered in Department of Biophysics, further encouraged me to pursue higher education. Guidance and support from Dr. Dongre, Professor and Head of the department, transformed my efforts into securing admit from USA’s universities.

Mr. Aditya Narvekar

I am Aditya Narvekar, currently pursuing Ph.D. at ICT, Mumbai, alumnus of the batch 2014-16 of the Department of Biophysics, University of Mumbai. An interdisciplinary subject for my masters and biophysics was the most appropriate choice. It is a highly vibrant field where researchers from fields such as physics, chemistry, biology, engineering, material sciences etc. use their knowledge and skills to understand and develop new tools in order to understand how life works. It forms a bridging science where complex systems such as molecules, cells, organisms and ecosystems are understood better through physical and chemical principles. Thus, life processes such as nervous communication, photosynthesis, metabolism, energetics, tumorigenesis are understood from quantitative perspectives of physics and chemistry. The subject thus, gives a detailed view of any life process under consideration. The department is well equipped with state-of-the-art facilities which allow research in various areas of biophysics. Instrument accessibility, in-depth discussion, coursework flexibility with project work, job opportunity and alumni suggestions are the keep parameters that should be explored by the department for additional efficiency.

Ms. Zehra Haider

Living systems are highly complex systems where all the fundamental forces and interactions take place in a wonderfully coordinated manner. Hence, biology in itself is not a separate science, but a system driven by fundamental forces of physics and chemical interactions between the atoms which can be derived by mathematical equations. Therefore, it is impossible to study it completely with any single branch of science. Biophysics provides with the opportunity to decipher the complete picture by taking in to account all the branches of science that come into play. Biophysics being an interdisciplinary science provides opportunities for students from all the backgrounds. This subject has given me a broader perspective and multiple points of view to study the living systems in more efficient ways. But most of the labs in India usually limit it to techniques rather than employing it to understand the fundamental concepts. In my opinion, there should be more focus on understanding the basic behaviour of living molecules and systems from the point of view of all the branches of science.

CONFERENCES /SYMPOSIA/WORKSHOPS/ INVITED TALKS ORGANISED

ORGANIZED CONFERENCES/SYMPOSIA

  Date Title of organized conference/symposia
 

1.

 

Dec 2010

 

Fluorescence steady state and lifetime analysis

 

2.

 

Feb 2011

 

Advanced techniques in Radiation Biophysics

 

3.

 

Feb 2012

 

National Seminar on “Structural biology and bioinformatics”

 

4.

 

Jan 2013

 

National Symposium (IBS) on frontiers of Biophysics, Biotechnology, Bioinformatics

 

5.

 

Feb 2014

 

Advances in Bioimaging

 

6.

 

Sep 2014

 

Biopotential and Signal Processing

 

7.

 

July 2015

 

Emerging Opportunities and Rewarding Carrier of Radiation and Cancer Research (CAREER-RCR)

 

8.

 

Mar 2016

 

Biophysics Week – “Workshop and Seminar on advanced Biophysical techniques”

 

9.

 

Jun 2016

 

National Seminar on “Impact of Climate change on Human health with respect to vector borne and water borne diseases” in association with CSIR

NEERI, Mumbai

 

10.

 

Aug 2018

 Two Days Mini Symposium – Workshop on Biophysics
 

10.

 

Aug 2019

 

Two Days Mini Symposium – Workshop on Biophysics

 

11.

 

Nov 2019

 

Workshop On Exploring Biophysical Techniques For Protein Purification And Characterization

 

 

INVITED TALKS

Sr.

No.

Date Topic Speaker
1. 05th Sept 2007 “Trends in protein NMR” Prof. K.V.R. Chary, Dept. of Chemical Sciences, TIFR, Mumbai
2. 21st Jan 2008 “Overview of simulation software for nanotechnology and biotechnology” Dr. Sivram Venkatraman and Dr. Chaudhary, Senior Staff Scientists, Accelerys, Bangalore
3. 29th Jan 2008 “An introduction to nanobiology” Dr. Nagraj Huilgol, Chief Radiation

Oncologist, Dr. Balabhai Nanvati Hospital & MRC, Mumbai

4. 20th Feb 2008 “Mechanism of genome repair process” Dr. B. Jagadeshwar Rao, Prof. and Chair, Dept. of Biological Sciences, TIFR, Mumbai
5. 15th Jan 2009 “Development of prophylactic vaccine using high-quality

recombinant subunit protein”

Dr. Suresh Patil Member of Indian American Council(IAC)
6. 26th Aug 2009 “Confocal laser scanning microscopy technique” Mr. Anil Kundaliya, Lab India Ltd.
7. 07th Jan 2010 “A newer approach for treatment of wound infections and role of immunity in health

and disease”

Prof. B.S. Nagoba, Asst. Dean, MIMSR Medical College.
8. 22nd Oct 2010 “Aptamer Technology” Wei Duan , School of Medicine, Deakin University, Australia
9. 19th Nov 2010 “Oxidatively generated DNA damage in cells: formation and measurement” Prof. Jean Cadet, Scientific Advisor, French Atomic Energy Commission, Adjunct Professor, University of

Sherbrook, Canada.

11. 3rd June 2011 “Exploring the human body by magnetic resonance imaging and MR Spectroscopy Dr. N.R. Jagannathan, Prof. and Head, Department of NMR & MRI facility, All India Institute of Medical

Science, New Delhi

12. 28th Sep 2011 “World leading Biotechnology at the University of Queensland – Technological response to global change” Prof. Ross Barnard, Biotechnology Program Director, School of Chemistry and Molecular Biosciences, Faculty of Science,

University of Queensland

13. 20th Dec 2011 “Surviving Starvation-Lessons from a Processive Exopolyphosphatase” David A. Sanders, Markey Center for Structural Biology, Department of Biological Sciences, Purdue

University, US

14. 27th Aug 2012 “Information, knowledge and Life in the 21st century” Dr. B Vijnana, IIT Kharagpur
15. 21st Jan 2013 Oxidative stress induced DNA damage Dr. Jean Cadet, Scientific Advisor
16. 29th Aug 2013 Cancer cell signalling process Dr. B N Pandey, Department of radiobiology & Health Sciences, BARC, Mumbai
17. 10th Sept 2013 “Radiation Dosimetry” Dr. S D Sharma, Head, Medical physics, section RP & AD, BARC
18. 08th Oct 2013 Introduction of application of

Multiphoton and confocal microscopy

Dr. Rishi kant (Carl Zeiss India)
19. 28th Nov 2014 “Membrane Channel and Neurotoxins” Prof. Peter N Strong, Sheffield Hallam University
20. 21st Aug 2014 “NMR in Biology and Medicine” Prof. Girjesh Govil, Emeritus Scientist, TIFR, Mumbai
21. 26th Aug 2014 Radiation In Cancer Therapy Prof. G D Maru, ACTREC, Navi Mumbai
22. 18th Mar 2015 An overview of education, Training and clinical role in

Healthcare

Dr. Indra J Das, Prof. & Director of Medical Physics, Indiana University.
23. March 2015 “Opportunities in Biophysics” Prof. T P Singh, Department of Biophysics, AIIMS, New Delhi
25. Aug 2016 Opportunities to Biophysicist in India and Abroad Prof Sudipta Maiti, Department of Chemical Sciences, TIFR, Mumbai
26. 15th Dec 2017 Food Radiation Safety:

Misconceptions and Apprehensions

Dr. S. Gautam, Scientific Officer, Food Technology Division, BARC
27. 7th Jan 2018 The human AP endonuclease APE1 in regulating resistance to radiation and chemotherapy Dr. Ramator D, Prof of Medicine, Montreal University, Canada
28. 16th Feb 2018 Novel Nanotechnologies in Biomedical Applications Dr. Pramod Avati, Department of Biophysics, PGIMER, Chandigarh
29. 29th Aug 2018 Biophysics and Protein Diseases Dr. Prabhat Singh, Scientific Officer, BARC, Mumbai
30. 12th Feb 2019 Texture analysis of CT and MR data – ready for routine clinical use” Dr. Balaji Ganeshan , UK Imaging Scientist, Institute of Nuclear Medicine, University College

London (UCL), United Kingdom

31 15th Mar 2019 Cargo stalling at actin-rich

regions causes local traffic jams in neurons

Dr. Sandhya Koushika, Associate

Professor, Department of Biological Sciences, TIFR, Mumbai

32. 22nd Mar 2019 Perspectives of Biomedical Raman Spectroscopy Dr. C. Murali Krishna, PI and Scientific Officer, ACTREC, Mumbai
33. 22nd Mar 2019 MMP-cytoskeletal crosstalk in cancer invasion Dr. Shamik Sen, Associate Professor, Department of Biosciences, IIT B
34. 27th Mar 2019 Structure and Biophysics guided

look at 14-3-3 protein, peptide interactions

Dr. Prasanna Venkatraman, Professor, ACTREC, Navi Mumbai
35. 29th Mar 2019 Forces and Energies at microscopic scale in Biology Dr. Ambarish Kunwar, Assistant Professor, Department of Biosciences, IIT B

 

MEDIA COVERAGE